Longevity-modulating effects of symbiosis: insights from Drosophila–Wolbachia interaction
Microbial communities are known to significantly affect various fitness components and survival of their insect hosts, including Drosophila . The composition of symbiotic microbiota has been shown to change with the host’s aging. It is unclear whether these changes are caused by the aging process or...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2016-11, Vol.17 (5-6), p.785-803 |
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| creator | Maistrenko, Oleksandr M. Serga, Svitlana V. Vaiserman, Alexander M. Kozeretska, Iryna A. |
| description | Microbial communities are known to significantly affect various fitness components and survival of their insect hosts, including
Drosophila
. The composition of symbiotic microbiota has been shown to change with the host’s aging. It is unclear whether these changes are caused by the aging process or, vice versa, they affect the host’s aging and longevity. Recent findings indicate that fitness and lifespan of
Drosophila
are affected by endosymbiotic bacteria
Wolbachia
. These effects, however, are inconsistent and have been reported both to extend and shorten longevity. The main molecular pathways underlying the lifespan-modulating effects of
Wolbachia
remain unclear, however insulin/insulin-like growth factor, immune deficiency, ecdysteroid synthesis and signaling and c-Jun N-terminal kinase pathways as well as heat shock protein synthesis and autophagy have been proposed to play a role. Here we revise the current evidence that elucidates the impact of
Wolbachia
endosymbionts on the aging processes in
Drosophila
. |
| doi_str_mv | 10.1007/s10522-016-9653-9 |
| format | Article |
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Drosophila
. The composition of symbiotic microbiota has been shown to change with the host’s aging. It is unclear whether these changes are caused by the aging process or, vice versa, they affect the host’s aging and longevity. Recent findings indicate that fitness and lifespan of
Drosophila
are affected by endosymbiotic bacteria
Wolbachia
. These effects, however, are inconsistent and have been reported both to extend and shorten longevity. The main molecular pathways underlying the lifespan-modulating effects of
Wolbachia
remain unclear, however insulin/insulin-like growth factor, immune deficiency, ecdysteroid synthesis and signaling and c-Jun N-terminal kinase pathways as well as heat shock protein synthesis and autophagy have been proposed to play a role. Here we revise the current evidence that elucidates the impact of
Wolbachia
endosymbionts on the aging processes in
Drosophila
.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-016-9653-9</identifier><identifier>PMID: 27230747</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aging - physiology ; Animals ; Bacterial Proteins - metabolism ; Biomedical and Life Sciences ; Cell Biology ; Developmental Biology ; Drosophila ; Drosophila - microbiology ; Drosophila - physiology ; Drosophila Proteins - metabolism ; Geriatrics/Gerontology ; Life Sciences ; Longevity - physiology ; Models, Biological ; Review Article ; Symbiosis - physiology ; Wolbachia ; Wolbachia - physiology</subject><ispartof>Biogerontology (Dordrecht), 2016-11, Vol.17 (5-6), p.785-803</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-c700941beb79f9cf8c12b3e519dc40a8f1b49da73567e1f1d8e90350837fa43e3</citedby><cites>FETCH-LOGICAL-c453t-c700941beb79f9cf8c12b3e519dc40a8f1b49da73567e1f1d8e90350837fa43e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-016-9653-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-016-9653-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,776,780,788,27899,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27230747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maistrenko, Oleksandr M.</creatorcontrib><creatorcontrib>Serga, Svitlana V.</creatorcontrib><creatorcontrib>Vaiserman, Alexander M.</creatorcontrib><creatorcontrib>Kozeretska, Iryna A.</creatorcontrib><title>Longevity-modulating effects of symbiosis: insights from Drosophila–Wolbachia interaction</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>Microbial communities are known to significantly affect various fitness components and survival of their insect hosts, including
Drosophila
. The composition of symbiotic microbiota has been shown to change with the host’s aging. It is unclear whether these changes are caused by the aging process or, vice versa, they affect the host’s aging and longevity. Recent findings indicate that fitness and lifespan of
Drosophila
are affected by endosymbiotic bacteria
Wolbachia
. These effects, however, are inconsistent and have been reported both to extend and shorten longevity. The main molecular pathways underlying the lifespan-modulating effects of
Wolbachia
remain unclear, however insulin/insulin-like growth factor, immune deficiency, ecdysteroid synthesis and signaling and c-Jun N-terminal kinase pathways as well as heat shock protein synthesis and autophagy have been proposed to play a role. Here we revise the current evidence that elucidates the impact of
Wolbachia
endosymbionts on the aging processes in
Drosophila
.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Developmental Biology</subject><subject>Drosophila</subject><subject>Drosophila - microbiology</subject><subject>Drosophila - physiology</subject><subject>Drosophila Proteins - metabolism</subject><subject>Geriatrics/Gerontology</subject><subject>Life Sciences</subject><subject>Longevity - physiology</subject><subject>Models, Biological</subject><subject>Review Article</subject><subject>Symbiosis - physiology</subject><subject>Wolbachia</subject><subject>Wolbachia - physiology</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkcuKFDEUhoMoc38AN1Lgxk00J6nc3Mno6EDDbEZczCKkUkl3hqpKm1QJvZt38A19EtP0KCIIQiAh-c5_yPkQeg7kNRAi3xQgnFJMQGAtOMP6CToBLhkWUqin9cyUxlxSfYxOS7knFaSCH6FjKikjspUn6G6VprX_FucdHlO_DHaO07rxIXg3lyaFpuzGLqYSy9smTiWuN_U65DQ273MqabuJg_3x8P1LGjrrNtFWaPbZujmm6Rw9C3Yo_uJxP0Ofrz7cXn7Cq5uP15fvVti1nM3YSUJ0C53vpA7aBeWAdsxz0L1riVUBulb3VjIupIcAvfKaME4Uk8G2zLMz9OqQu83p6-LLbMZYnB8GO_m0FAOVpLou_h8oFUJJAFLRl3-h92nJU_3InlJKgBayUnCgXB1HyT6YbY6jzTsDxOwlmYMkU2dv9pKMrjUvHpOXbvT974pfVipAD0CpT1VP_qP1P1N_Agcqnck</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Maistrenko, Oleksandr M.</creator><creator>Serga, Svitlana V.</creator><creator>Vaiserman, Alexander M.</creator><creator>Kozeretska, Iryna A.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>POGQB</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PRQQA</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20161101</creationdate><title>Longevity-modulating effects of symbiosis: insights from Drosophila–Wolbachia interaction</title><author>Maistrenko, Oleksandr M. ; Serga, Svitlana V. ; Vaiserman, Alexander M. ; Kozeretska, Iryna A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-c700941beb79f9cf8c12b3e519dc40a8f1b49da73567e1f1d8e90350837fa43e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aging - 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Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maistrenko, Oleksandr M.</au><au>Serga, Svitlana V.</au><au>Vaiserman, Alexander M.</au><au>Kozeretska, Iryna A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longevity-modulating effects of symbiosis: insights from Drosophila–Wolbachia interaction</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>17</volume><issue>5-6</issue><spage>785</spage><epage>803</epage><pages>785-803</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>Microbial communities are known to significantly affect various fitness components and survival of their insect hosts, including
Drosophila
. The composition of symbiotic microbiota has been shown to change with the host’s aging. It is unclear whether these changes are caused by the aging process or, vice versa, they affect the host’s aging and longevity. Recent findings indicate that fitness and lifespan of
Drosophila
are affected by endosymbiotic bacteria
Wolbachia
. These effects, however, are inconsistent and have been reported both to extend and shorten longevity. The main molecular pathways underlying the lifespan-modulating effects of
Wolbachia
remain unclear, however insulin/insulin-like growth factor, immune deficiency, ecdysteroid synthesis and signaling and c-Jun N-terminal kinase pathways as well as heat shock protein synthesis and autophagy have been proposed to play a role. Here we revise the current evidence that elucidates the impact of
Wolbachia
endosymbionts on the aging processes in
Drosophila
.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>27230747</pmid><doi>10.1007/s10522-016-9653-9</doi><tpages>19</tpages></addata></record> |
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| identifier | ISSN: 1389-5729 |
| ispartof | Biogerontology (Dordrecht), 2016-11, Vol.17 (5-6), p.785-803 |
| issn | 1389-5729 1573-6768 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aging - physiology Animals Bacterial Proteins - metabolism Biomedical and Life Sciences Cell Biology Developmental Biology Drosophila Drosophila - microbiology Drosophila - physiology Drosophila Proteins - metabolism Geriatrics/Gerontology Life Sciences Longevity - physiology Models, Biological Review Article Symbiosis - physiology Wolbachia Wolbachia - physiology |
| title | Longevity-modulating effects of symbiosis: insights from Drosophila–Wolbachia interaction |
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