Temporal increase in thymocyte negative selection parallels enhanced thymic SIRP alpha super(+) DC function
Dysregulation of negative selection contributes to T-cell-mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection, however, are ill defined. Work by our group and others suggest that negative selection is inefficient early in ontogeny and increases with age. T...
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| Veröffentlicht in: | European journal of immunology 2016-10, Vol.46 (10), p.2352-2362 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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