Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life
An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of Drosophila melanogaster subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The nove...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2016-11, Vol.17 (5-6), p.883-892 |
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| creator | Gomez, Federico H. Sambucetti, Pablo Norry, Fabian M. |
| description | An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of
Drosophila melanogaster
subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype. |
| doi_str_mv | 10.1007/s10522-016-9658-4 |
| format | Article |
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Drosophila melanogaster
subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-016-9658-4</identifier><identifier>PMID: 27488377</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adults ; Aging - genetics ; Animals ; Animals, Inbred Strains - genetics ; Biomedical and Life Sciences ; Cell Biology ; Developmental Biology ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; Drosophila Proteins - genetics ; Female ; Gene Expression Regulation, Developmental - genetics ; Genotype & phenotype ; Geriatrics/Gerontology ; Heat ; Heat-Shock Response - genetics ; Hormesis ; Hormesis - genetics ; Insects ; Life Sciences ; Longevity - genetics ; Male ; Quantitative Trait Loci - genetics ; Recombination, Genetic - genetics ; Research Article ; Sex Characteristics ; Thermotolerance - genetics</subject><ispartof>Biogerontology (Dordrecht), 2016-11, Vol.17 (5-6), p.883-892</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-88f38fe926bc643a9ad3997cc974a89ece749a51180b14994ca55c077b3687d63</citedby><cites>FETCH-LOGICAL-c475t-88f38fe926bc643a9ad3997cc974a89ece749a51180b14994ca55c077b3687d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-016-9658-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-016-9658-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27488377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomez, Federico H.</creatorcontrib><creatorcontrib>Sambucetti, Pablo</creatorcontrib><creatorcontrib>Norry, Fabian M.</creatorcontrib><title>Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of
Drosophila melanogaster
subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype.</description><subject>Adults</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Animals, Inbred Strains - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Developmental Biology</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Genotype & phenotype</subject><subject>Geriatrics/Gerontology</subject><subject>Heat</subject><subject>Heat-Shock Response - genetics</subject><subject>Hormesis</subject><subject>Hormesis - genetics</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Longevity - genetics</subject><subject>Male</subject><subject>Quantitative Trait Loci - genetics</subject><subject>Recombination, Genetic - genetics</subject><subject>Research Article</subject><subject>Sex Characteristics</subject><subject>Thermotolerance - genetics</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rFTEUhgdR7Jc_wI0E3LgZm0y-l1KrFQrd2PWQyZy5NyWTXJNMcX6I_9cMt4oIgqscOM95kpy3aV4T_J5gLC8zwbzrWkxEqwVXLXvWnBIuaSukUM9rTZVuuez0SXOW8wOuYCf4y-akk0wpKuVp8-Paw6MpMCL4XiBkFwOKE_Ix7ODRlRUNK7Kr9c4a71e0B1NQLglydmGHDMpQNj6BjfPgggkFuTCk6vMuQN56H1PM8bB33qAZvAlxZ3KBhMo-xWW3j0upJbiEzLj4UucmuGheTMZnePV0njf3n66_Xt20t3efv1x9uG0tk7y0Sk1UTaA7MVjBqNFmpFpLa7VkRmmwIJk2nBCFB8K0ZtZwbrGUAxVKjoKeN--O3kOK3xbIpZ9dtuDrKyEuuSd1SZ0WFOv_QDshGSVys779C32ISwr1IxullOBYbUJypGzdT04w9YfkZpPWnuB-i7c_xtvX1Pot3p7VmTdP5mWYYfw98SvPCnRHINdWjTD9cfU_rT8BkAOyGQ</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Gomez, Federico H.</creator><creator>Sambucetti, Pablo</creator><creator>Norry, Fabian M.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life</title><author>Gomez, Federico H. ; Sambucetti, Pablo ; Norry, Fabian M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-88f38fe926bc643a9ad3997cc974a89ece749a51180b14994ca55c077b3687d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adults</topic><topic>Aging - genetics</topic><topic>Animals</topic><topic>Animals, Inbred Strains - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Developmental Biology</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Genotype & phenotype</topic><topic>Geriatrics/Gerontology</topic><topic>Heat</topic><topic>Heat-Shock Response - genetics</topic><topic>Hormesis</topic><topic>Hormesis - genetics</topic><topic>Insects</topic><topic>Life Sciences</topic><topic>Longevity - genetics</topic><topic>Male</topic><topic>Quantitative Trait Loci - genetics</topic><topic>Recombination, Genetic - genetics</topic><topic>Research Article</topic><topic>Sex Characteristics</topic><topic>Thermotolerance - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez, Federico H.</creatorcontrib><creatorcontrib>Sambucetti, Pablo</creatorcontrib><creatorcontrib>Norry, Fabian M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez, Federico H.</au><au>Sambucetti, Pablo</au><au>Norry, Fabian M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>17</volume><issue>5-6</issue><spage>883</spage><epage>892</epage><pages>883-892</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of
Drosophila melanogaster
subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>27488377</pmid><doi>10.1007/s10522-016-9658-4</doi><tpages>10</tpages></addata></record> |
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| ispartof | Biogerontology (Dordrecht), 2016-11, Vol.17 (5-6), p.883-892 |
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| subjects | Adults Aging - genetics Animals Animals, Inbred Strains - genetics Biomedical and Life Sciences Cell Biology Developmental Biology Drosophila melanogaster Drosophila melanogaster - genetics Drosophila Proteins - genetics Female Gene Expression Regulation, Developmental - genetics Genotype & phenotype Geriatrics/Gerontology Heat Heat-Shock Response - genetics Hormesis Hormesis - genetics Insects Life Sciences Longevity - genetics Male Quantitative Trait Loci - genetics Recombination, Genetic - genetics Research Article Sex Characteristics Thermotolerance - genetics |
| title | Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
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