Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys
We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson’s disease. In this study, we explored whether NIr reduces the gliosis i...
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| Veröffentlicht in: | Experimental brain research 2016-11, Vol.234 (11), p.3225-3232 |
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| creator | El Massri, Nabil Moro, Cécile Torres, Napoleon Darlot, Fannie Agay, Diane Chabrol, Claude Johnstone, Daniel M. Stone, Jonathan Benabid, Alim-Louis Mitrofanis, John |
| description | We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson’s disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson’s disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr. |
| doi_str_mv | 10.1007/s00221-016-4720-7 |
| format | Article |
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In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson’s disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-016-4720-7</identifier><identifier>PMID: 27377070</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology ; Adenosine ; Analysis of Variance ; Animals ; Astrocytomas ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Corpus Striatum - metabolism ; Corpus Striatum - pathology ; Cytochrome ; Disease Models, Animal ; DNA-Binding Proteins - metabolism ; Enzymes ; Female ; Glial Fibrillary Acidic Protein - metabolism ; Gliosis - etiology ; Gliosis - therapy ; Infrared Rays - therapeutic use ; Laboratory animals ; Macaca fascicularis ; Male ; Monkeys & apes ; MPTP Poisoning - complications ; MPTP Poisoning - pathology ; Neuroglia - drug effects ; Neuroglia - radiation effects ; Neurology ; Neurosciences ; Neurotoxins - toxicity ; Parkinson disease ; Parkinson's disease ; Patient outcomes ; Phototherapy ; Research Article ; Substantia Nigra - drug effects ; Substantia Nigra - metabolism ; Substantia Nigra - pathology</subject><ispartof>Experimental brain research, 2016-11, Vol.234 (11), p.3225-3232</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-28829bdc61090fd4d67ac20dee1670fd532c44537c60abf0bc21cd5667ff8d063</citedby><cites>FETCH-LOGICAL-c537t-28829bdc61090fd4d67ac20dee1670fd532c44537c60abf0bc21cd5667ff8d063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00221-016-4720-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00221-016-4720-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27377070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Massri, Nabil</creatorcontrib><creatorcontrib>Moro, Cécile</creatorcontrib><creatorcontrib>Torres, Napoleon</creatorcontrib><creatorcontrib>Darlot, Fannie</creatorcontrib><creatorcontrib>Agay, Diane</creatorcontrib><creatorcontrib>Chabrol, Claude</creatorcontrib><creatorcontrib>Johnstone, Daniel M.</creatorcontrib><creatorcontrib>Stone, Jonathan</creatorcontrib><creatorcontrib>Benabid, Alim-Louis</creatorcontrib><creatorcontrib>Mitrofanis, John</creatorcontrib><title>Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><addtitle>Exp Brain Res</addtitle><description>We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson’s disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson’s disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology</subject><subject>Adenosine</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Astrocytomas</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Care and treatment</subject><subject>Corpus Striatum - metabolism</subject><subject>Corpus Striatum - pathology</subject><subject>Cytochrome</subject><subject>Disease Models, Animal</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Enzymes</subject><subject>Female</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Gliosis - etiology</subject><subject>Gliosis - therapy</subject><subject>Infrared Rays - therapeutic use</subject><subject>Laboratory animals</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Monkeys & apes</subject><subject>MPTP Poisoning - complications</subject><subject>MPTP Poisoning - pathology</subject><subject>Neuroglia - drug effects</subject><subject>Neuroglia - radiation effects</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurotoxins - toxicity</subject><subject>Parkinson disease</subject><subject>Parkinson's disease</subject><subject>Patient outcomes</subject><subject>Phototherapy</subject><subject>Research Article</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - metabolism</subject><subject>Substantia Nigra - pathology</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10k1v1DAQBmALgehS-AFcUCQkBAeXsZPY2WNV8VFUoIJytrzOJOuSxMXjSPTf47AFugjkQ-TJ846s0TD2WMCRANAvCUBKwUEoXmkJXN9hK1GVkgsB6i5bAYiKV41YH7AHRJfLtdRwnx1IXWoNGlbs3Qe0kfupizZiWwy-36YiRbRpxCkVuTY7pMJSiqEffCBPhZ-K9-cX5_wny6ExTF_xmh6ye50dCB_dfA_Zl9evLk7e8rOPb05Pjs-4q0uduGwaud60TglYQ9dWrdLWSWgRhdK5UJfSVVWmToHddLBxUri2Vkp3XdOCKg_Z813fqxi-zUjJjJ4cDoOdMMxkRFNquVaiEZk-_YtehjlO-XWLAqmElPBH9XZAk2cRUrRuaWqOKw2q1krVWR39Q-XT4uhdmLDzub4XeLEXyCbh99Tbmcicfv60b5_dslu0Q9pSGObkw0T7UOygi4EoYmeuoh9tvDYCzLIUZrcUJi-FWZbC6Jx5cjOFeTNi-zvxawsykDtA-dfUY7w1pv92_QHxL71f</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>El Massri, Nabil</creator><creator>Moro, Cécile</creator><creator>Torres, Napoleon</creator><creator>Darlot, Fannie</creator><creator>Agay, Diane</creator><creator>Chabrol, Claude</creator><creator>Johnstone, Daniel M.</creator><creator>Stone, Jonathan</creator><creator>Benabid, Alim-Louis</creator><creator>Mitrofanis, John</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>0-V</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20161101</creationdate><title>Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys</title><author>El Massri, Nabil ; Moro, Cécile ; Torres, Napoleon ; Darlot, Fannie ; Agay, Diane ; Chabrol, Claude ; Johnstone, Daniel M. ; Stone, Jonathan ; Benabid, Alim-Louis ; Mitrofanis, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-28829bdc61090fd4d67ac20dee1670fd532c44537c60abf0bc21cd5667ff8d063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology</topic><topic>Adenosine</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Astrocytomas</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Care and treatment</topic><topic>Corpus Striatum - metabolism</topic><topic>Corpus Striatum - pathology</topic><topic>Cytochrome</topic><topic>Disease Models, Animal</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Enzymes</topic><topic>Female</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Gliosis - etiology</topic><topic>Gliosis - therapy</topic><topic>Infrared Rays - therapeutic use</topic><topic>Laboratory animals</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Monkeys & apes</topic><topic>MPTP Poisoning - complications</topic><topic>MPTP Poisoning - pathology</topic><topic>Neuroglia - drug effects</topic><topic>Neuroglia - radiation effects</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurotoxins - toxicity</topic><topic>Parkinson disease</topic><topic>Parkinson's disease</topic><topic>Patient outcomes</topic><topic>Phototherapy</topic><topic>Research Article</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - metabolism</topic><topic>Substantia Nigra - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Massri, Nabil</creatorcontrib><creatorcontrib>Moro, Cécile</creatorcontrib><creatorcontrib>Torres, Napoleon</creatorcontrib><creatorcontrib>Darlot, Fannie</creatorcontrib><creatorcontrib>Agay, Diane</creatorcontrib><creatorcontrib>Chabrol, Claude</creatorcontrib><creatorcontrib>Johnstone, Daniel M.</creatorcontrib><creatorcontrib>Stone, Jonathan</creatorcontrib><creatorcontrib>Benabid, Alim-Louis</creatorcontrib><creatorcontrib>Mitrofanis, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Massri, Nabil</au><au>Moro, Cécile</au><au>Torres, Napoleon</au><au>Darlot, Fannie</au><au>Agay, Diane</au><au>Chabrol, Claude</au><au>Johnstone, Daniel M.</au><au>Stone, Jonathan</au><au>Benabid, Alim-Louis</au><au>Mitrofanis, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><addtitle>Exp Brain Res</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>234</volume><issue>11</issue><spage>3225</spage><epage>3232</epage><pages>3225-3232</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><abstract>We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson’s disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson’s disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27377070</pmid><doi>10.1007/s00221-016-4720-7</doi><tpages>8</tpages></addata></record> |
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| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Adenosine Analysis of Variance Animals Astrocytomas Biomedical and Life Sciences Biomedicine Care and treatment Corpus Striatum - metabolism Corpus Striatum - pathology Cytochrome Disease Models, Animal DNA-Binding Proteins - metabolism Enzymes Female Glial Fibrillary Acidic Protein - metabolism Gliosis - etiology Gliosis - therapy Infrared Rays - therapeutic use Laboratory animals Macaca fascicularis Male Monkeys & apes MPTP Poisoning - complications MPTP Poisoning - pathology Neuroglia - drug effects Neuroglia - radiation effects Neurology Neurosciences Neurotoxins - toxicity Parkinson disease Parkinson's disease Patient outcomes Phototherapy Research Article Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - pathology |
| title | Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys |
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