The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers

The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers

Highlights • Endocrine disrupting chemicals (obesogens) may contribute to the obesity epidemic. • PPARγ and RXRα are master regulators of adipogenesis. • Span 80 binds to and transactivates RXRα and promotes adipogenesis in vitro. • Corexit crude oil dispersants contain the putative obesogens DOSS a...

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Veröffentlicht in:General and comparative endocrinology 2016-11, Vol.238, p.61-68
Hauptverfasser: Bowers, Robert R, Temkin, Alexis M, Guillette, Louis J, Baatz, John E, Spyropoulos, Demetri D
Format: Artikel
Sprache:eng
Schlagworte:
3T3-L1 Cells
Adipocytes - drug effects
Adipocytes - metabolism
Adipogenesis - drug effects
Animals
Dioctyl Sulfosuccinic Acid - pharmacology
Emulsifying Agents - pharmacology
Endocrinology & Metabolism
Food
HEK293 Cells
Hexoses - pharmacology
Humans
Mice
Obesity - pathology
Oleic Acid - pharmacology
Petroleum
Petroleum Pollution
PPAR gamma - genetics
Retinoid X Receptor alpha - genetics
Surface-Active Agents - pharmacology
Transcriptional Activation - drug effects
Transcriptional Activation - genetics
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Zusammenfassung:Highlights • Endocrine disrupting chemicals (obesogens) may contribute to the obesity epidemic. • PPARγ and RXRα are master regulators of adipogenesis. • Span 80 binds to and transactivates RXRα and promotes adipogenesis in vitro. • Corexit crude oil dispersants contain the putative obesogens DOSS and Span 80.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2016.04.029