Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro

Abstract Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to the...

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Veröffentlicht in:	Brain research 2016-11, Vol.1651, p.17-26
Hauptverfasser:	Pogačnik, Lea, Pirc, Katja, Palmela, Inês, Skrt, Mihaela, Kwang, Kim S, Brites, Dora, Brito, Maria Alexandra, Ulrih, Nataša Poklar, Silva, Rui F.M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Animals Anthocyanins - pharmacokinetics Anthocyanins - pharmacology Antioxidants - pharmacokinetics Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Blood–brain barrier Brain - drug effects Brain - metabolism Catechin - analogs & derivatives Catechin - pharmacokinetics Catechin - pharmacology Cells, Cultured Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drug Stability Endothelial Cells - drug effects Endothelial Cells - metabolism Flavonoids Flavonoids - pharmacokinetics Flavonoids - pharmacology Glucosides - pharmacokinetics Glucosides - pharmacology Humans Necrosis Necrosis - drug therapy Necrosis - metabolism Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology Protein Multimerization - drug effects Quercetin - pharmacokinetics Quercetin - pharmacology Rats, Wistar Recombinant Proteins - metabolism α-synuclein fibrillation
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