Novel pH-sensitive polysialic acid based polymeric micelles for triggered intracellular release of hydrophobic drug

•A novel intracellular pH-sensitive amphiphilic copolymer PSAU was synthesized.•PTX-loaded-PSAU exhibited well-defined spherical shape and particle size.•The drug-loading was 4.5% with an entrapment efficiency of 67.5%.•PTX-loaded-PSAU micelles could efficiently release PTX in tumor cells. Polysiali...

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