l-Arginine ethylester enhances in vitro amplification of PrPSc in macaques with atypical L-type bovine spongiform encephalopathy and enables presymptomatic detection of PrPSc in the bodily fluids

Protease-resistant, misfolded isoforms (PrPSc) of a normal cellular prion protein (PrPC) in the bodily fluids, including blood, urine, and saliva, are expected to be useful diagnostic markers of prion diseases, and nonhuman primate models are suited for performing valid diagnostic tests for human Cr...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-02, Vol.470 (3), p.563-568
Hauptverfasser:	Murayama, Y., Ono, F., Shimozaki, N., Shibata, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine ethylester Atypical bovine spongiform encephalopathy Bodily fluid Macaca Nonhuman primate Protein misfolding cyclic amplification
Online-Zugang:	Volltext
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