Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways

Tea infused with the seed of Cassia obtusifolia has been traditionally used as an herbal remedy for liver, eye, and acute inflammatory diseases. Recent pharmacological reports have indicated that Cassiae semen has neuroprotective effects, attributable to its anti-inflammatory actions, in ischemic st...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-02, Vol.178, p.50-57
Hauptverfasser:	Yi, Jee Hyun, Park, Hey Jin, Lee, Seungheon, Jung, Ji Wook, Kim, Byeong C., Lee, Young Choon, Ryu, Jong Hoon, Kim, Dong Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amyloid beta Amyloid beta-Peptides - metabolism Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Cassia - chemistry Cassia obtusifolia Cassia obtusifolia seeds Chromosome Pairing - drug effects Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hippocampus - drug effects Hippocampus - metabolism Long-term potentiation Long-Term Potentiation - drug effects Male Memory - drug effects Memory Disorders - drug therapy Memory Disorders - metabolism Mice Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Proto-Oncogene Proteins c-akt - metabolism Recognition memory Seeds - chemistry Signal Transduction - drug effects
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