Dysphagia in Parkinson’s Disease
More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlyi...
Gespeichert in:
Veröffentlicht in: | Dysphagia 2016-02, Vol.31 (1), p.24-32 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 32 |
---|---|
container_issue | 1 |
container_start_page | 24 |
container_title | Dysphagia |
container_volume | 31 |
creator | Suttrup, Inga Warnecke, Tobias |
description | More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD patients is challenging and often delivers unreliable results. A modified water test assessing maximum swallowing volume is recommended to uncover oropharyngeal dysphagia in PD. PD-specific questionnaires may also be useful to identify patients at risk for swallowing impairment. Fiberoptic endoscopic evaluation of swallowing and videofluoroscopic swallowing study are both considered to be the gold standard for evaluation of PD-related dysphagia. In addition, high-resolution manometry may be a helpful tool. These instrumental methods allow a reliable detection of aspiration events. Furthermore, typical patterns of impairment during the oral, pharyngeal and/or esophageal swallowing phase of PD patients can be identified. Therapy of dysphagia in PD consists of pharmacological interventions and swallowing treatment by speech and language therapists (SLTs). Fluctuating dysphagia with deterioration during the off-state should be treated by optimizing dopaminergic medication. The methods used during swallowing treatment by SLTs shall be selected according to the individual dysphagia pattern of each PD patient. A promising novel method is an intensive training of expiratory muscle strength. Deep brain stimulation does not seem to have a clinical relevant effect on swallowing function in PD. The goal of this review is giving an overview on current stages of epidemiology, pathophysiology, diagnosis, and treatment of PD-associated dysphagia, which might be helpful for neurologists, speech-language therapists, and other clinicians in their daily work with PD patients and associated swallowing difficulties. Furthermore areas with an urgent need for future clinical research are identified. |
doi_str_mv | 10.1007/s00455-015-9671-9 |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837295033</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712959747</galeid><sourcerecordid>A712959747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-3808d61933de3fced03024c084404b25aebad04f841894645d47263e226e2d463</originalsourceid><addsrcrecordid>eNqFkbtOIzEUhi3ECsLlAWhQBA3NwLF9bI9LFK4S0m4B0naWM3MmGJKZYCcFHa_B6_Ek6ygsuyAQcmHJ_v5fPv4Y2-FwyAHMUQJApQrgqrDa8MKusB5HKQpADausB9zYAhT_vc42UroD4MJqucbWhVYWlBE9tnfymKa3fhR8P7T9Xz7ehzZ17cvTc-qfhEQ-0Rb70fhxou3XfZPdnJ1eDy6Kq5_nl4Pjq6JSKGaFLKGsNbdS1iSbimqQILCCEhFwKJSnoa8BmxJ5aVGjqtEILUkITaJGLTfZwbJ3GruHOaWZm4RU0XjsW-rmyfFSGmEVSPk9arRSJecCM7r_Ab3r5rHNgywozH1ai3_UyI_JhbbpZtFXi1J3bPKvKWvQZOrwEyqvmiah6lpqQj5_F-DLQBW7lCI1bhrDxMdHx8EtFLqlQpcVuoVCZ3Nm9_XB8-GE6rfEX2cZEEsg5at2RPG_ib5s_QPRiaFi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1764950662</pqid></control><display><type>article</type><title>Dysphagia in Parkinson’s Disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Suttrup, Inga ; Warnecke, Tobias</creator><creatorcontrib>Suttrup, Inga ; Warnecke, Tobias</creatorcontrib><description>More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD patients is challenging and often delivers unreliable results. A modified water test assessing maximum swallowing volume is recommended to uncover oropharyngeal dysphagia in PD. PD-specific questionnaires may also be useful to identify patients at risk for swallowing impairment. Fiberoptic endoscopic evaluation of swallowing and videofluoroscopic swallowing study are both considered to be the gold standard for evaluation of PD-related dysphagia. In addition, high-resolution manometry may be a helpful tool. These instrumental methods allow a reliable detection of aspiration events. Furthermore, typical patterns of impairment during the oral, pharyngeal and/or esophageal swallowing phase of PD patients can be identified. Therapy of dysphagia in PD consists of pharmacological interventions and swallowing treatment by speech and language therapists (SLTs). Fluctuating dysphagia with deterioration during the off-state should be treated by optimizing dopaminergic medication. The methods used during swallowing treatment by SLTs shall be selected according to the individual dysphagia pattern of each PD patient. A promising novel method is an intensive training of expiratory muscle strength. Deep brain stimulation does not seem to have a clinical relevant effect on swallowing function in PD. The goal of this review is giving an overview on current stages of epidemiology, pathophysiology, diagnosis, and treatment of PD-associated dysphagia, which might be helpful for neurologists, speech-language therapists, and other clinicians in their daily work with PD patients and associated swallowing difficulties. Furthermore areas with an urgent need for future clinical research are identified.</description><identifier>ISSN: 0179-051X</identifier><identifier>EISSN: 1432-0460</identifier><identifier>DOI: 10.1007/s00455-015-9671-9</identifier><identifier>PMID: 26590572</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Deglutition disorders ; Deglutition Disorders - diagnosis ; Deglutition Disorders - etiology ; Deglutition Disorders - physiopathology ; Deglutition Disorders - therapy ; Development and progression ; Epidemiology ; Gastroenterology ; Hepatology ; Humans ; Imaging ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Otorhinolaryngology ; Parkinson Disease - complications ; Parkinson Disease - diagnosis ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Parkinson's disease ; Radiology ; Review Article</subject><ispartof>Dysphagia, 2016-02, Vol.31 (1), p.24-32</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-3808d61933de3fced03024c084404b25aebad04f841894645d47263e226e2d463</citedby><cites>FETCH-LOGICAL-c542t-3808d61933de3fced03024c084404b25aebad04f841894645d47263e226e2d463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00455-015-9671-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00455-015-9671-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,776,780,788,27899,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26590572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suttrup, Inga</creatorcontrib><creatorcontrib>Warnecke, Tobias</creatorcontrib><title>Dysphagia in Parkinson’s Disease</title><title>Dysphagia</title><addtitle>Dysphagia</addtitle><addtitle>Dysphagia</addtitle><description>More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD patients is challenging and often delivers unreliable results. A modified water test assessing maximum swallowing volume is recommended to uncover oropharyngeal dysphagia in PD. PD-specific questionnaires may also be useful to identify patients at risk for swallowing impairment. Fiberoptic endoscopic evaluation of swallowing and videofluoroscopic swallowing study are both considered to be the gold standard for evaluation of PD-related dysphagia. In addition, high-resolution manometry may be a helpful tool. These instrumental methods allow a reliable detection of aspiration events. Furthermore, typical patterns of impairment during the oral, pharyngeal and/or esophageal swallowing phase of PD patients can be identified. Therapy of dysphagia in PD consists of pharmacological interventions and swallowing treatment by speech and language therapists (SLTs). Fluctuating dysphagia with deterioration during the off-state should be treated by optimizing dopaminergic medication. The methods used during swallowing treatment by SLTs shall be selected according to the individual dysphagia pattern of each PD patient. A promising novel method is an intensive training of expiratory muscle strength. Deep brain stimulation does not seem to have a clinical relevant effect on swallowing function in PD. The goal of this review is giving an overview on current stages of epidemiology, pathophysiology, diagnosis, and treatment of PD-associated dysphagia, which might be helpful for neurologists, speech-language therapists, and other clinicians in their daily work with PD patients and associated swallowing difficulties. Furthermore areas with an urgent need for future clinical research are identified.</description><subject>Deglutition disorders</subject><subject>Deglutition Disorders - diagnosis</subject><subject>Deglutition Disorders - etiology</subject><subject>Deglutition Disorders - physiopathology</subject><subject>Deglutition Disorders - therapy</subject><subject>Development and progression</subject><subject>Epidemiology</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Otorhinolaryngology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - therapy</subject><subject>Parkinson's disease</subject><subject>Radiology</subject><subject>Review Article</subject><issn>0179-051X</issn><issn>1432-0460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkbtOIzEUhi3ECsLlAWhQBA3NwLF9bI9LFK4S0m4B0naWM3MmGJKZYCcFHa_B6_Ek6ygsuyAQcmHJ_v5fPv4Y2-FwyAHMUQJApQrgqrDa8MKusB5HKQpADausB9zYAhT_vc42UroD4MJqucbWhVYWlBE9tnfymKa3fhR8P7T9Xz7ehzZ17cvTc-qfhEQ-0Rb70fhxou3XfZPdnJ1eDy6Kq5_nl4Pjq6JSKGaFLKGsNbdS1iSbimqQILCCEhFwKJSnoa8BmxJ5aVGjqtEILUkITaJGLTfZwbJ3GruHOaWZm4RU0XjsW-rmyfFSGmEVSPk9arRSJecCM7r_Ab3r5rHNgywozH1ai3_UyI_JhbbpZtFXi1J3bPKvKWvQZOrwEyqvmiah6lpqQj5_F-DLQBW7lCI1bhrDxMdHx8EtFLqlQpcVuoVCZ3Nm9_XB8-GE6rfEX2cZEEsg5at2RPG_ib5s_QPRiaFi</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Suttrup, Inga</creator><creator>Warnecke, Tobias</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Dysphagia in Parkinson’s Disease</title><author>Suttrup, Inga ; Warnecke, Tobias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-3808d61933de3fced03024c084404b25aebad04f841894645d47263e226e2d463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Deglutition disorders</topic><topic>Deglutition Disorders - diagnosis</topic><topic>Deglutition Disorders - etiology</topic><topic>Deglutition Disorders - physiopathology</topic><topic>Deglutition Disorders - therapy</topic><topic>Development and progression</topic><topic>Epidemiology</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Otorhinolaryngology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - therapy</topic><topic>Parkinson's disease</topic><topic>Radiology</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suttrup, Inga</creatorcontrib><creatorcontrib>Warnecke, Tobias</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Dysphagia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suttrup, Inga</au><au>Warnecke, Tobias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dysphagia in Parkinson’s Disease</atitle><jtitle>Dysphagia</jtitle><stitle>Dysphagia</stitle><addtitle>Dysphagia</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>31</volume><issue>1</issue><spage>24</spage><epage>32</epage><pages>24-32</pages><issn>0179-051X</issn><eissn>1432-0460</eissn><abstract>More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD patients is challenging and often delivers unreliable results. A modified water test assessing maximum swallowing volume is recommended to uncover oropharyngeal dysphagia in PD. PD-specific questionnaires may also be useful to identify patients at risk for swallowing impairment. Fiberoptic endoscopic evaluation of swallowing and videofluoroscopic swallowing study are both considered to be the gold standard for evaluation of PD-related dysphagia. In addition, high-resolution manometry may be a helpful tool. These instrumental methods allow a reliable detection of aspiration events. Furthermore, typical patterns of impairment during the oral, pharyngeal and/or esophageal swallowing phase of PD patients can be identified. Therapy of dysphagia in PD consists of pharmacological interventions and swallowing treatment by speech and language therapists (SLTs). Fluctuating dysphagia with deterioration during the off-state should be treated by optimizing dopaminergic medication. The methods used during swallowing treatment by SLTs shall be selected according to the individual dysphagia pattern of each PD patient. A promising novel method is an intensive training of expiratory muscle strength. Deep brain stimulation does not seem to have a clinical relevant effect on swallowing function in PD. The goal of this review is giving an overview on current stages of epidemiology, pathophysiology, diagnosis, and treatment of PD-associated dysphagia, which might be helpful for neurologists, speech-language therapists, and other clinicians in their daily work with PD patients and associated swallowing difficulties. Furthermore areas with an urgent need for future clinical research are identified.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26590572</pmid><doi>10.1007/s00455-015-9671-9</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0179-051X |
ispartof | Dysphagia, 2016-02, Vol.31 (1), p.24-32 |
issn | 0179-051X 1432-0460 |
language | eng |
recordid | cdi_proquest_miscellaneous_1837295033 |
source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Deglutition disorders Deglutition Disorders - diagnosis Deglutition Disorders - etiology Deglutition Disorders - physiopathology Deglutition Disorders - therapy Development and progression Epidemiology Gastroenterology Hepatology Humans Imaging Medical research Medicine Medicine & Public Health Medicine, Experimental Otorhinolaryngology Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Radiology Review Article |
title | Dysphagia in Parkinson’s Disease |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T13%3A40%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dysphagia%20in%20Parkinson%E2%80%99s%20Disease&rft.jtitle=Dysphagia&rft.au=Suttrup,%20Inga&rft.date=2016-02-01&rft.volume=31&rft.issue=1&rft.spage=24&rft.epage=32&rft.pages=24-32&rft.issn=0179-051X&rft.eissn=1432-0460&rft_id=info:doi/10.1007/s00455-015-9671-9&rft_dat=%3Cgale_proqu%3EA712959747%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1764950662&rft_id=info:pmid/26590572&rft_galeid=A712959747&rfr_iscdi=true |