Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors
[Display omitted] Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized...
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| Veröffentlicht in: | International journal of pharmaceutics 2014-08, Vol.471 (1-2), p.166-172 |
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| container_end_page | 172 |
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| container_issue | 1-2 |
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| container_title | International journal of pharmaceutics |
| container_volume | 471 |
| creator | Lee, Ung Yeol Oh, Young Taik Kim, Dongin Lee, Eun Seong |
| description | [Display omitted]
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo. |
| doi_str_mv | 10.1016/j.ijpharm.2014.05.028 |
| format | Article |
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Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2014.05.028</identifier><identifier>PMID: 24858385</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cell Line, Tumor ; Chlorin e6 (Ce6) ; Drug Carriers - chemistry ; Drug Liberation ; Female ; Grain-marked micelles ; Humans ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles - chemistry ; Mice, Nude ; Micelles ; Multimeric micelles ; Neoplasms - drug therapy ; Neoplasms - pathology ; Photochemotherapy - methods ; Photodynamic therapy ; Porphyrins - administration & dosage ; Porphyrins - chemistry ; Radiation-Sensitizing Agents - administration & dosage ; Radiation-Sensitizing Agents - chemistry ; Surface Properties ; Xenograft Model Antitumor Assays</subject><ispartof>International journal of pharmaceutics, 2014-08, Vol.471 (1-2), p.166-172</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-a9503bf643843adb7d72e79ede3db20ca8db23283bd57b98550ee6b2dbdbf7103</citedby><cites>FETCH-LOGICAL-c398t-a9503bf643843adb7d72e79ede3db20ca8db23283bd57b98550ee6b2dbdbf7103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2014.05.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24858385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ung Yeol</creatorcontrib><creatorcontrib>Oh, Young Taik</creatorcontrib><creatorcontrib>Kim, Dongin</creatorcontrib><creatorcontrib>Lee, Eun Seong</creatorcontrib><title>Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Chlorin e6 (Ce6)</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Liberation</subject><subject>Female</subject><subject>Grain-marked micelles</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Mice, Nude</subject><subject>Micelles</subject><subject>Multimeric micelles</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Porphyrins - administration & dosage</subject><subject>Porphyrins - chemistry</subject><subject>Radiation-Sensitizing Agents - administration & dosage</subject><subject>Radiation-Sensitizing Agents - chemistry</subject><subject>Surface Properties</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP1DAQhC0EYmcXfgLIRy4JfsSxc0JoxWOlRVzgbDl2Z-IhsYOdIM2_x9EMXPfUUumrbnUVQm8oqSmh7ftT7U_LaNJcM0KbmoiaMPUMHaiSvOKNbJ-jA-FSVYJKfoNucz4RQlpG-Ut0wxolFFfigPK3bVr9DMlbfEzGh2o26Rc4PHsL0wQZDzHh0R_H6YxhGLz1EFa8jHGN7hxMwfA6QjLLGZtQbOYYYC1ighyDCRawL5oPRxwHvG5zTPkVejGYKcPr67xDPz9_-nH_tXr8_uXh_uNjZXmn1sp0gvB-aBuuGm5cL51kIDtwwF3PiDWqDM4U752QfaeEIABtz1zv-kFSwu_Qu8veJcXfG-RVzz7vX5kAccuaKi5Zx1vGnkZFQ7naYyuouKA2xZwTDHpJ5cV01pTovRp90tdq9F6NJkKXaorv7fXE1s_g_rv-dVGADxcASiZ_PCSd97AtOJ_ArtpF_8SJv4HjpRI</recordid><startdate>20140825</startdate><enddate>20140825</enddate><creator>Lee, Ung Yeol</creator><creator>Oh, Young Taik</creator><creator>Kim, Dongin</creator><creator>Lee, Eun Seong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20140825</creationdate><title>Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors</title><author>Lee, Ung Yeol ; Oh, Young Taik ; Kim, Dongin ; Lee, Eun Seong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-a9503bf643843adb7d72e79ede3db20ca8db23283bd57b98550ee6b2dbdbf7103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Chlorin e6 (Ce6)</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Liberation</topic><topic>Female</topic><topic>Grain-marked micelles</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Mice, Nude</topic><topic>Micelles</topic><topic>Multimeric micelles</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Porphyrins - administration & dosage</topic><topic>Porphyrins - chemistry</topic><topic>Radiation-Sensitizing Agents - administration & dosage</topic><topic>Radiation-Sensitizing Agents - chemistry</topic><topic>Surface Properties</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ung Yeol</creatorcontrib><creatorcontrib>Oh, Young Taik</creatorcontrib><creatorcontrib>Kim, Dongin</creatorcontrib><creatorcontrib>Lee, Eun Seong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ung Yeol</au><au>Oh, Young Taik</au><au>Kim, Dongin</au><au>Lee, Eun Seong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2014-08-25</date><risdate>2014</risdate><volume>471</volume><issue>1-2</issue><spage>166</spage><epage>172</epage><pages>166-172</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24858385</pmid><doi>10.1016/j.ijpharm.2014.05.028</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of pharmaceutics, 2014-08, Vol.471 (1-2), p.166-172 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cell Line, Tumor Chlorin e6 (Ce6) Drug Carriers - chemistry Drug Liberation Female Grain-marked micelles Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Mice, Nude Micelles Multimeric micelles Neoplasms - drug therapy Neoplasms - pathology Photochemotherapy - methods Photodynamic therapy Porphyrins - administration & dosage Porphyrins - chemistry Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - chemistry Surface Properties Xenograft Model Antitumor Assays |
| title | Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors |
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