Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP

Maintenance of intracellular proteostasis is essential for neuronal function, and emerging data support the view that disturbed proteostasis plays an important role in brain aging and the pathogenesis of age-related neurodegenerative disorders such as Alzheimer’s disease (AD). sAPPalpha (sAPPα), the...

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Veröffentlicht in:	Molecular neurobiology 2016-11, Vol.53 (9), p.5985-5994
Hauptverfasser:	Kundu, Arpita, Milosch, Nelli, Antonietti, Patrick, Baumkötter, Frederik, Zymny, Andreas, Müller, Ulrike C., Kins, Stefan, Hajieva, Parvana, Behl, Christian, Kögel, Donat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Amyloid beta-Protein Precursor - metabolism Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Biomedical and Life Sciences Biomedicine Caspases - metabolism Cell Biology Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - metabolism Humans Leupeptins - pharmacology Mice, Inbred C57BL Neurobiology Neurology Neurosciences Peptide Fragments - metabolism Proteasome Endopeptidase Complex - metabolism Recombinant Proteins - pharmacology
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