Performance of magnetic chitosan–alginate core–shell beads for increasing the bioavailability of a low permeable drug
[Display omitted] •Magnetic chitosan–alginate core–shell beads were designed for oral administration.•Magnetic retention increases low permeable drug absorption.•The adsorbed fraction in human is expected to reach 70% thanks to a correlation low. This work reports the synthesis and performance of ma...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2014-10, Vol.88 (2), p.374-381 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
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| creator | Seth, Anjali Lafargue, David Poirier, Cécile Péan, Jean-Manuel Ménager, Christine |
| description | [Display omitted]
•Magnetic chitosan–alginate core–shell beads were designed for oral administration.•Magnetic retention increases low permeable drug absorption.•The adsorbed fraction in human is expected to reach 70% thanks to a correlation low.
This work reports the synthesis and performance of magnetic chitosan–alginate core–shell beads for oral administration of small molecules in order to increase their bioavailability. For this purpose, we designed magnetic core–shell beads suitable for oral delivery that are resistant in acidic media (stomach pH), mucoadhesive, exhibit a superparamagnetic behavior and a very high entrapment efficiency. Ex vivo experiments were performed in Ussing chambers, to emphasize the effect of magnetic accumulation. The amount of drug permeated through the membrane exhibited a threefold increase with our novel drug delivery system. According to a correlation law, our ex vivo model showed that the adsorbed fraction (FA) in human is expected to reach 70% when using the magnetic retention system which is a great improvement when compared to the controls (FA=20%). |
| doi_str_mv | 10.1016/j.ejpb.2014.05.017 |
| format | Article |
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•Magnetic chitosan–alginate core–shell beads were designed for oral administration.•Magnetic retention increases low permeable drug absorption.•The adsorbed fraction in human is expected to reach 70% thanks to a correlation low.
This work reports the synthesis and performance of magnetic chitosan–alginate core–shell beads for oral administration of small molecules in order to increase their bioavailability. For this purpose, we designed magnetic core–shell beads suitable for oral delivery that are resistant in acidic media (stomach pH), mucoadhesive, exhibit a superparamagnetic behavior and a very high entrapment efficiency. Ex vivo experiments were performed in Ussing chambers, to emphasize the effect of magnetic accumulation. The amount of drug permeated through the membrane exhibited a threefold increase with our novel drug delivery system. According to a correlation law, our ex vivo model showed that the adsorbed fraction (FA) in human is expected to reach 70% when using the magnetic retention system which is a great improvement when compared to the controls (FA=20%).</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2014.05.017</identifier><identifier>PMID: 24859307</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Absorption ; Alginate ; Alginates - chemistry ; Animals ; Bioavailability ; Biological Availability ; Chitosan ; Chitosan - chemistry ; Drug delivery ; Glucuronic Acid - chemistry ; Hexuronic Acids - chemistry ; Humans ; Magnetic particles ; Magnetics ; Male ; Microscopy, Electron, Scanning ; Permeability ; Pharmacokinetics ; Rats ; Rats, Wistar</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2014-10, Vol.88 (2), p.374-381</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-e8847c6970bab8b35869e661a88e83f0511f948814a23351ff76883072282e193</citedby><cites>FETCH-LOGICAL-c422t-e8847c6970bab8b35869e661a88e83f0511f948814a23351ff76883072282e193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939641114001672$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24859307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seth, Anjali</creatorcontrib><creatorcontrib>Lafargue, David</creatorcontrib><creatorcontrib>Poirier, Cécile</creatorcontrib><creatorcontrib>Péan, Jean-Manuel</creatorcontrib><creatorcontrib>Ménager, Christine</creatorcontrib><title>Performance of magnetic chitosan–alginate core–shell beads for increasing the bioavailability of a low permeable drug</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>[Display omitted]
•Magnetic chitosan–alginate core–shell beads were designed for oral administration.•Magnetic retention increases low permeable drug absorption.•The adsorbed fraction in human is expected to reach 70% thanks to a correlation low.
This work reports the synthesis and performance of magnetic chitosan–alginate core–shell beads for oral administration of small molecules in order to increase their bioavailability. For this purpose, we designed magnetic core–shell beads suitable for oral delivery that are resistant in acidic media (stomach pH), mucoadhesive, exhibit a superparamagnetic behavior and a very high entrapment efficiency. Ex vivo experiments were performed in Ussing chambers, to emphasize the effect of magnetic accumulation. The amount of drug permeated through the membrane exhibited a threefold increase with our novel drug delivery system. 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•Magnetic chitosan–alginate core–shell beads were designed for oral administration.•Magnetic retention increases low permeable drug absorption.•The adsorbed fraction in human is expected to reach 70% thanks to a correlation low.
This work reports the synthesis and performance of magnetic chitosan–alginate core–shell beads for oral administration of small molecules in order to increase their bioavailability. For this purpose, we designed magnetic core–shell beads suitable for oral delivery that are resistant in acidic media (stomach pH), mucoadhesive, exhibit a superparamagnetic behavior and a very high entrapment efficiency. Ex vivo experiments were performed in Ussing chambers, to emphasize the effect of magnetic accumulation. The amount of drug permeated through the membrane exhibited a threefold increase with our novel drug delivery system. According to a correlation law, our ex vivo model showed that the adsorbed fraction (FA) in human is expected to reach 70% when using the magnetic retention system which is a great improvement when compared to the controls (FA=20%).</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24859307</pmid><doi>10.1016/j.ejpb.2014.05.017</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of pharmaceutics and biopharmaceutics, 2014-10, Vol.88 (2), p.374-381 |
| issn | 0939-6411 1873-3441 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Absorption Alginate Alginates - chemistry Animals Bioavailability Biological Availability Chitosan Chitosan - chemistry Drug delivery Glucuronic Acid - chemistry Hexuronic Acids - chemistry Humans Magnetic particles Magnetics Male Microscopy, Electron, Scanning Permeability Pharmacokinetics Rats Rats, Wistar |
| title | Performance of magnetic chitosan–alginate core–shell beads for increasing the bioavailability of a low permeable drug |
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