Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study

•We examined the association of prenatal smoking and polymorphism with birth size.•Eight genotypes encoding PAH-metabolizing and DNA-repair genes were investigated.•Polymorphisms were analyzed in 3263 healthy pregnant Japanese women.•We observed adverse birth effects with the combination of AHR, CYP...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2016-10, Vol.65, p.295-306
Hauptverfasser:	Kobayashi, Sumitaka, Sata, Fumihiro, Sasaki, Seiko, Braimoh, Titilola Serifat, Araki, Atsuko, Miyashita, Chihiro, Goudarzi, Houman, Kobayashi, Sachiko, Kishi, Reiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aromatic hydrocarbon receptor (AHR) Biomarkers - analysis Birth size Birth Weight Cytochrome P-450 CYP1A1 - genetics Cytochrome P450 1A1 (CYP1A1) Female Genotype Humans Infant, Newborn Japan Male Maternal smoking Maternal-Fetal Exchange Pregnancy Receptors, Aryl Hydrocarbon - genetics Smoking - genetics X-ray Repair Cross Complementing Protein 1 - genetics X-ray – complementing gene 1 (XRCC1) Young Adult
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