Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study
•We examined the association of prenatal smoking and polymorphism with birth size.•Eight genotypes encoding PAH-metabolizing and DNA-repair genes were investigated.•Polymorphisms were analyzed in 3263 healthy pregnant Japanese women.•We observed adverse birth effects with the combination of AHR, CYP...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2016-10, Vol.65, p.295-306 |
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| creator | Kobayashi, Sumitaka Sata, Fumihiro Sasaki, Seiko Braimoh, Titilola Serifat Araki, Atsuko Miyashita, Chihiro Goudarzi, Houman Kobayashi, Sachiko Kishi, Reiko |
| description | •We examined the association of prenatal smoking and polymorphism with birth size.•Eight genotypes encoding PAH-metabolizing and DNA-repair genes were investigated.•Polymorphisms were analyzed in 3263 healthy pregnant Japanese women.•We observed adverse birth effects with the combination of AHR, CYP1A1 and XRCC1.•Prenatal smoking and AHR/CYP1A1/XRCC1 SNPs are associated with reduced birth size.
We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size.
Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off=11.48ng/mL). We conducted data analysis using multiple linear regression models.
Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, −145g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: −241, −50).
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size. |
| doi_str_mv | 10.1016/j.reprotox.2016.08.020 |
| format | Article |
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We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size.
Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off=11.48ng/mL). We conducted data analysis using multiple linear regression models.
Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, −145g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: −241, −50).
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2016.08.020</identifier><identifier>PMID: 27592400</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aromatic hydrocarbon receptor (AHR) ; Biomarkers - analysis ; Birth size ; Birth Weight ; Cytochrome P-450 CYP1A1 - genetics ; Cytochrome P450 1A1 (CYP1A1) ; Female ; Genotype ; Humans ; Infant, Newborn ; Japan ; Male ; Maternal smoking ; Maternal-Fetal Exchange ; Pregnancy ; Receptors, Aryl Hydrocarbon - genetics ; Smoking - genetics ; X-ray Repair Cross Complementing Protein 1 - genetics ; X-ray – complementing gene 1 (XRCC1) ; Young Adult</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2016-10, Vol.65, p.295-306</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-4234bdd247f21d6b68385adbb14aeee5d3a778ab9f915e1584809ffed853b8923</citedby><cites>FETCH-LOGICAL-c559t-4234bdd247f21d6b68385adbb14aeee5d3a778ab9f915e1584809ffed853b8923</cites><orcidid>0000-0001-8173-9269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.reprotox.2016.08.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27592400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Sumitaka</creatorcontrib><creatorcontrib>Sata, Fumihiro</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Braimoh, Titilola Serifat</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Goudarzi, Houman</creatorcontrib><creatorcontrib>Kobayashi, Sachiko</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><title>Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>•We examined the association of prenatal smoking and polymorphism with birth size.•Eight genotypes encoding PAH-metabolizing and DNA-repair genes were investigated.•Polymorphisms were analyzed in 3263 healthy pregnant Japanese women.•We observed adverse birth effects with the combination of AHR, CYP1A1 and XRCC1.•Prenatal smoking and AHR/CYP1A1/XRCC1 SNPs are associated with reduced birth size.
We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size.
Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off=11.48ng/mL). We conducted data analysis using multiple linear regression models.
Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, −145g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: −241, −50).
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size.</description><subject>Adult</subject><subject>Aromatic hydrocarbon receptor (AHR)</subject><subject>Biomarkers - analysis</subject><subject>Birth size</subject><subject>Birth Weight</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Cytochrome P450 1A1 (CYP1A1)</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Japan</subject><subject>Male</subject><subject>Maternal smoking</subject><subject>Maternal-Fetal Exchange</subject><subject>Pregnancy</subject><subject>Receptors, Aryl Hydrocarbon - genetics</subject><subject>Smoking - genetics</subject><subject>X-ray Repair Cross Complementing Protein 1 - genetics</subject><subject>X-ray – complementing gene 1 (XRCC1)</subject><subject>Young Adult</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQQC0EokvhFyofOTTBdpzY5sQSAYtUCVRAgpPlxJPWuxt7a3sRy2_ww7hsyxVOHo_ezGjmIXRGSU0J7V6s6wi7GHL4UbPyr4msCSMP0IJK0VRUEPkQLYhUpOpYI0_Qk5TWhBAulHiMTphoFeOELNCvPsyD82AxTBOMOeEw4eXq8hz33z7SJT3Hxlv89bLvKb4CH_JhB-lPbhfBm2y2eDYZoi9BmsPG-SscPHZ-Mj7jwcV8jZP7CS_xaxdmEzcQsUkJUpqhAM7jfA14FTYb42zAn_LeHp6iR5PZJnh2956iL2_ffO5X1cWHd-_75UU1tq3KFWcNH6xlXEyM2m7oZCNbY4eBcgMArW2MENIMalK0BdpKLokqS1rZNoNUrDlFz499yyFv9pCynl0aYbs1HsI-aSobwRTpOv4_aMsbwpUoaHdExxhSijDpXXRl84OmRN-602t9707futNE6uKuFJ7dzdgPM9i_ZfeyCvDqCEA5yncHUafRgR_BuljUaRvcv2b8BgWyrsk</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Kobayashi, Sumitaka</creator><creator>Sata, Fumihiro</creator><creator>Sasaki, Seiko</creator><creator>Braimoh, Titilola Serifat</creator><creator>Araki, Atsuko</creator><creator>Miyashita, Chihiro</creator><creator>Goudarzi, Houman</creator><creator>Kobayashi, Sachiko</creator><creator>Kishi, Reiko</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0001-8173-9269</orcidid></search><sort><creationdate>201610</creationdate><title>Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study</title><author>Kobayashi, Sumitaka ; Sata, Fumihiro ; Sasaki, Seiko ; Braimoh, Titilola Serifat ; Araki, Atsuko ; Miyashita, Chihiro ; Goudarzi, Houman ; Kobayashi, Sachiko ; Kishi, Reiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-4234bdd247f21d6b68385adbb14aeee5d3a778ab9f915e1584809ffed853b8923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aromatic hydrocarbon receptor (AHR)</topic><topic>Biomarkers - analysis</topic><topic>Birth size</topic><topic>Birth Weight</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Cytochrome P450 1A1 (CYP1A1)</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Japan</topic><topic>Male</topic><topic>Maternal smoking</topic><topic>Maternal-Fetal Exchange</topic><topic>Pregnancy</topic><topic>Receptors, Aryl Hydrocarbon - genetics</topic><topic>Smoking - genetics</topic><topic>X-ray Repair Cross Complementing Protein 1 - genetics</topic><topic>X-ray – complementing gene 1 (XRCC1)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Sumitaka</creatorcontrib><creatorcontrib>Sata, Fumihiro</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Braimoh, Titilola Serifat</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Goudarzi, Houman</creatorcontrib><creatorcontrib>Kobayashi, Sachiko</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Sumitaka</au><au>Sata, Fumihiro</au><au>Sasaki, Seiko</au><au>Braimoh, Titilola Serifat</au><au>Araki, Atsuko</au><au>Miyashita, Chihiro</au><au>Goudarzi, Houman</au><au>Kobayashi, Sachiko</au><au>Kishi, Reiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2016-10</date><risdate>2016</risdate><volume>65</volume><spage>295</spage><epage>306</epage><pages>295-306</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>•We examined the association of prenatal smoking and polymorphism with birth size.•Eight genotypes encoding PAH-metabolizing and DNA-repair genes were investigated.•Polymorphisms were analyzed in 3263 healthy pregnant Japanese women.•We observed adverse birth effects with the combination of AHR, CYP1A1 and XRCC1.•Prenatal smoking and AHR/CYP1A1/XRCC1 SNPs are associated with reduced birth size.
We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size.
Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off=11.48ng/mL). We conducted data analysis using multiple linear regression models.
Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, −145g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: −241, −50).
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27592400</pmid><doi>10.1016/j.reprotox.2016.08.020</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8173-9269</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aromatic hydrocarbon receptor (AHR) Biomarkers - analysis Birth size Birth Weight Cytochrome P-450 CYP1A1 - genetics Cytochrome P450 1A1 (CYP1A1) Female Genotype Humans Infant, Newborn Japan Male Maternal smoking Maternal-Fetal Exchange Pregnancy Receptors, Aryl Hydrocarbon - genetics Smoking - genetics X-ray Repair Cross Complementing Protein 1 - genetics X-ray – complementing gene 1 (XRCC1) Young Adult |
| title | Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study |
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