Norepinephrine inhibits mesenchymal stem cell chemotaxis migration by increasing stromal cell-derived factor-1 secretion by vascular endothelial cells via NE/abrd3/JNK pathway

Mesenchymal stem cells (MSCs), which are physiologically maintained in vascular endothelial cell (VEC)-based niches, play a critical role in tissue regeneration. Our previous studies demonstrated that sympathetic denervation could promote MSC mobilization, thereby enhancing bone formation in distrac...

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Veröffentlicht in:	Experimental cell research 2016-12, Vol.349 (2), p.214-220
Hauptverfasser:	Wu, Baolei, Wang, Lei, Yang, Xi, Mao, Ming, Ye, Chen, Liu, Peng, Yang, Zihui, Yang, Xinjie, Lei, Delin, Zhang, Chenping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Regeneration - drug effects Bone Regeneration - physiology Cell adhesion & migration Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Cellular biology Chemokine CXCL12 - metabolism Chemotaxis - drug effects Chemotaxis - physiology Chemotaxis migration Distraction osteogenesis Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - secretion Male MAP Kinase Signaling System - physiology Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Norepinephrine Norepinephrine - metabolism Norepinephrine - pharmacology Osteogenesis - drug effects Osteogenesis - physiology Rats, Sprague-Dawley Stem cells Stromal cell-derived factor-1 Vascular endothelial cells
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