Cardiac Angiosarcoma: Histopathologic, Immunohistochemical, and Cytogenetic Analysis of 10 Cases

Angiosarcoma (AS) is the most common cardiac sarcoma with differentiation, and is poorly characterized from a molecular genetic standpoint. Prognosis remains poor, owing to several factors including aggressive tumor biology, poor response to adjuvant therapy, and lack of targeted therapy. The clinic...

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Veröffentlicht in:	Human pathology 2017-02, Vol.60, p.199-207
Hauptverfasser:	Leduc, Charles, MD, Jenkins, Sarah M., MS, Sukov, William R., MD, Rustin, Jeannette G., BS, Maleszewski, Joseph J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiosarcoma Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cardiac malignancy Cardiac tumors Chromosome Aberrations Cloning Cytogenetics Deoxyribonucleic acid DNA DNA Copy Number Variations Female Gangrene Gene Deletion Genetic Predisposition to Disease Genetic testing Genome-Wide Association Study Genomes Heart Neoplasms - chemistry Heart Neoplasms - diagnosis Heart Neoplasms - genetics Heart Neoplasms - pathology Heart Neoplasms - surgery Hemangiosarcoma - chemistry Hemangiosarcoma - diagnosis Hemangiosarcoma - genetics Hemangiosarcoma - pathology Hemangiosarcoma - surgery Humans Immunoglobulins Immunohistochemistry Kaplan-Meier Estimate Loss of Heterozygosity Male Medical prognosis Middle Aged Minnesota Molecular Diagnostic Techniques Molecular diagnostics Pathology Phenotype Polymorphism, Single Nucleotide Predictive Value of Tests Proportional Hazards Models Registries Software Time Factors Treatment Outcome Young Adult
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