GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation

Platelets are well known for their role in hemostasis but are also increasingly recognized for their supporting role in innate immune responses. Here, we studied the role of platelets in the development of peripheral inflammation and found that platelets colocalize with macrophages in the inflamed t...

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Veröffentlicht in:	Journal of investigative dermatology 2017-03, Vol.137 (3), p.686-695
Hauptverfasser:	Pierre, Sandra, Linke, Bona, Suo, Jing, Tarighi, Neda, Del Turco, Domenico, Thomas, Dominique, Ferreiros, Nerea, Stegner, David, Frölich, Stefanie, Sisignano, Marco, Meyer Dos Santos, Sascha, deBruin, Natasja, Nüsing, Rolf M., Deller, Thomas, Nieswandt, Bernhard, Geisslinger, Gerd, Scholich, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - metabolism Collagen - chemistry Female Gene Deletion Inflammation Lectins, C-Type - metabolism Macrophages - metabolism Male Mannose-Binding Lectins - metabolism Mice Mice, Inbred C57BL Phenotype Platelet Membrane Glycoproteins - metabolism Receptors, Cell Surface - metabolism Receptors, Thromboxane A2, Prostaglandin H2 - metabolism Skin - pathology Thromboxane A2 - metabolism
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