Keratin 17 is overexpressed and predicts poor survival in estrogen receptor–negative/human epidermal growth factor receptor-2–negative breast cancer

Clinicopathological features of breast cancer have limited accuracy to predict survival. By immunohistochemistry (IHC), keratin 17 (K17) expression has been correlated with triple-negative status (estrogen receptor [ER]/progesterone receptor/human epidermal growth factor receptor-2 [HER2] negative)...

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Veröffentlicht in:	Human pathology 2017-04, Vol.62, p.23-32
Hauptverfasser:	Merkin, Ross D., Vanner, Elizabeth A., Romeiser, Jamie L., Shroyer, A. Laurie W., Escobar-Hoyos, Luisa F., Li, Jinyu, Powers, Robert S., Burke, Stephanie, Shroyer, Kenneth R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Breast cancer Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - chemistry Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - mortality Carcinoma, Intraductal, Noninfiltrating - pathology Cell cycle Data Mining Databases, Genetic Datasets Disease-Free Survival Epidermal growth factor Female Gene expression Genomes Genomics Humans Immunohistochemistry Kaplan-Meier Estimate Keratin Keratin-17 - analysis Keratin-17 - genetics Laboratories Localization Medical prognosis Middle Aged Neoplasm Staging Patients Predictive Value of Tests Proportional Hazards Models Proteins Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Registries Risk Factors RNA, Messenger - genetics Studies Time Factors Triple Negative Breast Neoplasms - chemistry Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology Up-Regulation
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