Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series
Abstract Purpose To investigate the morphological changes of the corneal epithelium and sub-basal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). Design Case-control study of patients with corneal allodynia and healthy controls. Methods Ten eyes of six patients we...
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| Veröffentlicht in: | The ocular surface 2017-01, Vol.15 (1), p.139-151 |
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| creator | Hamrah, Pedram, M.D Qazi, Yureeda, M.D Shahatit, Bashar, M.D Dastjerdi, Mohammad H., M.D Pavan-Langston, Deborah, M.D Jacobs, Deborah S., M.D Rosenthal, Perry, M.D |
| description | Abstract Purpose To investigate the morphological changes of the corneal epithelium and sub-basal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). Design Case-control study of patients with corneal allodynia and healthy controls. Methods Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls. Images were retrospectively analyzed for number of corneal subbasal nerve main trunks and branches, total nerve length, tortuosity, corneal superficial and basal epithelial cell density and superficial epithelial cell size. Results Corneal allodynia was seen in patients with dry eye disease, recurrent erosion syndrome, exposure to ultraviolet radiation, and accutane use. Compared to controls, patients with corneal allodynia had a significant decrease in the total numbers of sub-basal nerves (p=0.02), nerve branches (p=0.006), total nerve length (p=0.009), total nerve density (p=0.009) and superficial and basal epithelial cell densities (p |
| doi_str_mv | 10.1016/j.jtos.2016.10.002 |
| format | Article |
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Design Case-control study of patients with corneal allodynia and healthy controls. Methods Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls. Images were retrospectively analyzed for number of corneal subbasal nerve main trunks and branches, total nerve length, tortuosity, corneal superficial and basal epithelial cell density and superficial epithelial cell size. Results Corneal allodynia was seen in patients with dry eye disease, recurrent erosion syndrome, exposure to ultraviolet radiation, and accutane use. Compared to controls, patients with corneal allodynia had a significant decrease in the total numbers of sub-basal nerves (p=0.02), nerve branches (p=0.006), total nerve length (p=0.009), total nerve density (p=0.009) and superficial and basal epithelial cell densities (p<0.001) with an increase in superficial epithelial cell size (p<0.01). There were no statistically significant differences in the number of subbasal main nerve trunks (p=0.07) and nerve tortuosity (p=0.13). Conclusions Corneal IVCM enables near-histological visualization and quantification of the cellular and neural changes in corneal allodynia. Corneal allodynia is associated with decreased corneal epithelial cell densities, increased epithelial cell size, and decreased numbers and lengths of subbasal nerves. IVCM may be useful in the management of patients with corneal allodynia.</description><identifier>ISSN: 1542-0124</identifier><identifier>EISSN: 1937-5913</identifier><identifier>DOI: 10.1016/j.jtos.2016.10.002</identifier><identifier>PMID: 27816571</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Case-Control Studies ; Cell Count ; confocal microscopy ; Cornea ; corneal allodynia ; Epithelial Cells ; Humans ; Hyperalgesia ; in vivo confocal microscopy ; Microscopy, Confocal ; nerve ; Ophthalmic Nerve ; Ophthalmology ; Ultraviolet Rays</subject><ispartof>The ocular surface, 2017-01, Vol.15 (1), p.139-151</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-3c9251f2674c1fe2c9d5aba2e88606f513a88e521214f3ff6b910e134b6583943</citedby><cites>FETCH-LOGICAL-c477t-3c9251f2674c1fe2c9d5aba2e88606f513a88e521214f3ff6b910e134b6583943</cites><orcidid>0000-0002-2727-4488 ; 0000-0002-5312-3106</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27816571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamrah, Pedram, M.D</creatorcontrib><creatorcontrib>Qazi, Yureeda, M.D</creatorcontrib><creatorcontrib>Shahatit, Bashar, M.D</creatorcontrib><creatorcontrib>Dastjerdi, Mohammad H., M.D</creatorcontrib><creatorcontrib>Pavan-Langston, Deborah, M.D</creatorcontrib><creatorcontrib>Jacobs, Deborah S., M.D</creatorcontrib><creatorcontrib>Rosenthal, Perry, M.D</creatorcontrib><title>Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series</title><title>The ocular surface</title><addtitle>Ocul Surf</addtitle><description>Abstract Purpose To investigate the morphological changes of the corneal epithelium and sub-basal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). Design Case-control study of patients with corneal allodynia and healthy controls. Methods Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls. Images were retrospectively analyzed for number of corneal subbasal nerve main trunks and branches, total nerve length, tortuosity, corneal superficial and basal epithelial cell density and superficial epithelial cell size. Results Corneal allodynia was seen in patients with dry eye disease, recurrent erosion syndrome, exposure to ultraviolet radiation, and accutane use. Compared to controls, patients with corneal allodynia had a significant decrease in the total numbers of sub-basal nerves (p=0.02), nerve branches (p=0.006), total nerve length (p=0.009), total nerve density (p=0.009) and superficial and basal epithelial cell densities (p<0.001) with an increase in superficial epithelial cell size (p<0.01). There were no statistically significant differences in the number of subbasal main nerve trunks (p=0.07) and nerve tortuosity (p=0.13). Conclusions Corneal IVCM enables near-histological visualization and quantification of the cellular and neural changes in corneal allodynia. Corneal allodynia is associated with decreased corneal epithelial cell densities, increased epithelial cell size, and decreased numbers and lengths of subbasal nerves. IVCM may be useful in the management of patients with corneal allodynia.</description><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>confocal microscopy</subject><subject>Cornea</subject><subject>corneal allodynia</subject><subject>Epithelial Cells</subject><subject>Humans</subject><subject>Hyperalgesia</subject><subject>in vivo confocal microscopy</subject><subject>Microscopy, Confocal</subject><subject>nerve</subject><subject>Ophthalmic Nerve</subject><subject>Ophthalmology</subject><subject>Ultraviolet Rays</subject><issn>1542-0124</issn><issn>1937-5913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0Eoh_wBzggH7lk8diJ4yCEtIpKqVTg0Jar5XXGwiFrL3Z2pf33ONqWAwdOHs2874znGULeAFsBA_l-XI1zzCte4pJYMcafkXPoRFs1HYjnJW5qXjHg9Rm5yHlkTEjJ-EtyxlsFsmnhnIQ-poBmot8wHZCaMNCrnZ9_4uRLssdpoutpxmRmH0OmPtAnw3qa4nAM3nyg60BvAv3hD7FUg4u2lL96m2K2cXekvclI7zB5zK_IC2emjK8f30vy8Pnqvv9S3X6_vunXt5Wt23auhO14A47LtrbgkNtuaMzGcFRKMukaEEYpbDhwqJ1wTm46YAii3shGia4Wl-Tdqe8uxd97zLPe-mzLNiZg3GcNSrSsjFCiSPlJuvw3J3R6l_zWpKMGphfOetQLZ71wXnKFczG9fey_32xx-Gt5AlsEH08CLFsePCadrcdgcfAJ7ayH6P_f_9M_djv54AvYX3jEPMZ9CoWfBp25ZvpuufRyaJCCsU5x8Qe4FKJ0</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Hamrah, Pedram, M.D</creator><creator>Qazi, Yureeda, M.D</creator><creator>Shahatit, Bashar, M.D</creator><creator>Dastjerdi, Mohammad H., M.D</creator><creator>Pavan-Langston, Deborah, M.D</creator><creator>Jacobs, Deborah S., M.D</creator><creator>Rosenthal, Perry, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2727-4488</orcidid><orcidid>https://orcid.org/0000-0002-5312-3106</orcidid></search><sort><creationdate>20170101</creationdate><title>Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series</title><author>Hamrah, Pedram, M.D ; Qazi, Yureeda, M.D ; Shahatit, Bashar, M.D ; Dastjerdi, Mohammad H., M.D ; Pavan-Langston, Deborah, M.D ; Jacobs, Deborah S., M.D ; Rosenthal, Perry, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-3c9251f2674c1fe2c9d5aba2e88606f513a88e521214f3ff6b910e134b6583943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>confocal microscopy</topic><topic>Cornea</topic><topic>corneal allodynia</topic><topic>Epithelial Cells</topic><topic>Humans</topic><topic>Hyperalgesia</topic><topic>in vivo confocal microscopy</topic><topic>Microscopy, Confocal</topic><topic>nerve</topic><topic>Ophthalmic Nerve</topic><topic>Ophthalmology</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamrah, Pedram, M.D</creatorcontrib><creatorcontrib>Qazi, Yureeda, M.D</creatorcontrib><creatorcontrib>Shahatit, Bashar, M.D</creatorcontrib><creatorcontrib>Dastjerdi, Mohammad H., M.D</creatorcontrib><creatorcontrib>Pavan-Langston, Deborah, M.D</creatorcontrib><creatorcontrib>Jacobs, Deborah S., M.D</creatorcontrib><creatorcontrib>Rosenthal, Perry, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The ocular surface</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamrah, Pedram, M.D</au><au>Qazi, Yureeda, M.D</au><au>Shahatit, Bashar, M.D</au><au>Dastjerdi, Mohammad H., M.D</au><au>Pavan-Langston, Deborah, M.D</au><au>Jacobs, Deborah S., M.D</au><au>Rosenthal, Perry, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series</atitle><jtitle>The ocular surface</jtitle><addtitle>Ocul Surf</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>15</volume><issue>1</issue><spage>139</spage><epage>151</epage><pages>139-151</pages><issn>1542-0124</issn><eissn>1937-5913</eissn><abstract>Abstract Purpose To investigate the morphological changes of the corneal epithelium and sub-basal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). Design Case-control study of patients with corneal allodynia and healthy controls. Methods Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls. Images were retrospectively analyzed for number of corneal subbasal nerve main trunks and branches, total nerve length, tortuosity, corneal superficial and basal epithelial cell density and superficial epithelial cell size. Results Corneal allodynia was seen in patients with dry eye disease, recurrent erosion syndrome, exposure to ultraviolet radiation, and accutane use. Compared to controls, patients with corneal allodynia had a significant decrease in the total numbers of sub-basal nerves (p=0.02), nerve branches (p=0.006), total nerve length (p=0.009), total nerve density (p=0.009) and superficial and basal epithelial cell densities (p<0.001) with an increase in superficial epithelial cell size (p<0.01). There were no statistically significant differences in the number of subbasal main nerve trunks (p=0.07) and nerve tortuosity (p=0.13). Conclusions Corneal IVCM enables near-histological visualization and quantification of the cellular and neural changes in corneal allodynia. Corneal allodynia is associated with decreased corneal epithelial cell densities, increased epithelial cell size, and decreased numbers and lengths of subbasal nerves. IVCM may be useful in the management of patients with corneal allodynia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27816571</pmid><doi>10.1016/j.jtos.2016.10.002</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2727-4488</orcidid><orcidid>https://orcid.org/0000-0002-5312-3106</orcidid></addata></record> |
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| subjects | Case-Control Studies Cell Count confocal microscopy Cornea corneal allodynia Epithelial Cells Humans Hyperalgesia in vivo confocal microscopy Microscopy, Confocal nerve Ophthalmic Nerve Ophthalmology Ultraviolet Rays |
| title | Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series |
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