Misoprostol modulates the gene expression prostaglandin E2 and oxidative stress markers in myometrial cells

Misoprostol, prostaglandin E1 analogue, used for labour induction. However, one-third of patients who have labour induced with prostaglandins do not reach vaginal delivery. The differential expression of prostaglandin receptors in myometrial cells could account for this differential response. Since...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2016-11, Vol.126, p.38-45
Hauptverfasser:	Konopka, Cristine Kolling, Azzolin, Verônica Farina, Cadoná, Francine Carla, Machado, Alencar Kolinski, Dornelles, Eduardo Bortoluzzi, Barbisan, Fernanda, da Cruz, Ivana Beatrice Mânica
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Dinoprostone - genetics Female Gene Expression Regulation - drug effects Humans Misoprostol - pharmacology mRNA Myometrium Myometrium - cytology Myometrium - drug effects Myometrium - metabolism Myometrium - physiology Oxidative Stress - drug effects Pharmacogenomic Pregnancy Prostaglandin receptors Term pregnancy Uterine Contraction - drug effects Uterus
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