Cytochrome P4501A induction and testosterone hydroxylation in cultured hepatocytes of four fish species

Primary hepatocytes of the rainbow trout ( Oncorhynchus mykiss), flounder ( Platychthis flesus), dab ( Limanda limanda) and lemon sole ( Microstomus kitt) were exposed to 3,3 ′4,4 ′5 pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) for two days. This resulted in a dose-de...

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Veröffentlicht in:	Chemosphere (Oxford) 2002, Vol.46 (2), p.163-172
Hauptverfasser:	Smeets, Jean M.W., Wamsteker, Jasper, Roth, Bart, Everaarts, Jan, van den Berg, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences CYP1A CYP1A protein Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P-450 CYP1A1 - pharmacology Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - pharmacology cytochrome P450 Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Environmental Pollutants - adverse effects Enzyme Induction Estrogen Antagonists - adverse effects Fish hepatocytes Fishes - physiology Fundamental and applied biological sciences. Psychology Hepatocytes - enzymology Hydroxylation Limanda limanda Male Microstomus kitt Oncorhynchus mykiss Oxidoreductases - biosynthesis Oxidoreductases - pharmacology PCB Platichthys flesus Polychlorinated Biphenyls - adverse effects Polychlorinated Dibenzodioxins - adverse effects TCDD Testosterone - metabolism Testosterone hydroxylation Water Pollutants, Chemical - adverse effects
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