Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk

Abstract Previous studies suggest that elevated total homocysteine levels and the methylenetetrahydrofolate reductase ( MTHFR) C677T polymorphism, which correlates with plasma total homocysteine levels, are risk factors for schizophrenia (SCZ). Recently, a large genome-wide association study (GWAS)...

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Veröffentlicht in:	Psychiatry research 2016-12, Vol.246, p.833-837
Hauptverfasser:	Kinoshita, Makoto, Numata, Shusuke, Tajima, Atsushi, Nishi, Akira, Muraki, Sho, Tsuchiya, Atsushi, Umehara, Hidehiro, Watanabe, Shin-ya, Imoto, Issei, Ohmori, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - blood Case-control association study Female Genetic Predisposition to Disease - genetics Genetic Predisposition to Disease - psychology Genetic Variation - genetics Genome-Wide Association Study - methods Genotype Genotype risk score Homocysteine - blood Homocysteine - genetics Humans Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Polymorphism, Single Nucleotide - genetics Psychiatry Risk Factors Schizophrenia - blood Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenic Psychology Single nucleotide polymorphism
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