Update on the genetic architecture of rheumatoid arthritis

Key Points The highly polygenic aetiology of rheumatoid arthritis (RA) is well characterized in population genetic studies, with >100 susceptibility loci reported Genetic variants affecting the structure of epitope-binding sites of HLA molecules exhibit the strongest contributions to RA developme...

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Veröffentlicht in:	Nature reviews. Rheumatology 2017-01, Vol.13 (1), p.13-24
Hauptverfasser:	Kim, Kwangwoo, Bang, So-Young, Lee, Hye-Soon, Bae, Sang-Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/2489/144 692/499 692/699/1670/498 Amino acids Antigens Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - blood Disease Disease susceptibility Drug Repositioning Genetic aspects Genetic Loci Genetic Predisposition to Disease HLA Antigens - genetics Humans Major Histocompatibility Complex - genetics Medicine & Public Health Pathogenesis Peptides Peptides, Cyclic - immunology Pharmacogenetics Phenotype Polymorphism, Single Nucleotide Regression analysis review-article Rheumatoid arthritis Rheumatology Risk factors Signal Transduction - genetics Single nucleotide polymorphisms
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