MtDNA: The small workhorse of evolutionary studies
The double-stranded, circular mitochondrial DNA (mtDNA), which is present in all eukaryotic life forms, was initially discovered and characterized in the last century and has been widely used in evolutionary studies. Since then, a large number of studies have taken advantage of the genetic informati...
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| Veröffentlicht in: | Frontiers in bioscience 2017-01, Vol.22 (5), p.873-887, Article 4522 |
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| container_title | Frontiers in bioscience |
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| creator | Desalle, Rob Schierwater, Bernd Hadrys, Heike |
| description | The double-stranded, circular mitochondrial DNA (mtDNA), which is present in all eukaryotic life forms, was initially discovered and characterized in the last century and has been widely used in evolutionary studies. Since then, a large number of studies have taken advantage of the genetic information encoded in this genome. Because of its small size in animals (in general), the technical ease of manipulating mitochondrial genome and the dynamics of its evolutionary change, this genome has been the workhorse of evolutionary studies over the past three decades. However, the ease with which nuclear DNA can be manipulated due to next generation sequencing (NGS) methods, has recently caused an expected dip in the use of mtDNA in evolutionary studies. This review examines the future of mitochondrial DNA as a useful tool in studies centered around evolution. |
| doi_str_mv | 10.2741/4522 |
| format | Article |
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This review examines the future of mitochondrial DNA as a useful tool in studies centered around evolution.</description><subject>Animals</subject><subject>DNA Barcoding, Taxonomic</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Evolution, Molecular</subject><subject>Genetics, Population</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Hominidae - genetics</subject><subject>Humans</subject><subject>Phylogeny</subject><subject>Phylogeography</subject><subject>Selection, Genetic</subject><issn>1093-9946</issn><issn>2768-6698</issn><issn>1093-4715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwkAYRSdGIwR4BdOFCzfVmW_-3RHEnwR1g-tmmH4N1ZbBmVbj2wsBXd3NycnNIWTM6DVowW6EBDghQ9DK5EpZc0qGjFqeWyvUgExSeqeUgmXMSnNOBqANE0rCkMBzd_cyvc2Wa8xS65om-w7xYx1iwixUGX6Fpu_qsHHxJ0tdX9aYxuSsck3CyXFH5O1-vpw95ovXh6fZdJF70LLLBaITAMKutONImaqo96BKK0FyUzLLKw2s5N5YKcErI1bcoXJKOO4Eaj4iVwfvNobPHlNXtHXy2DRug6FPBTNcac4Z4zv08oD6GFKKWBXbWLe7zwWjxT5QsQ-0wy6Oxn7VYvkP_eXgv1_GXPQ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Desalle, Rob</creator><creator>Schierwater, Bernd</creator><creator>Hadrys, Heike</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>MtDNA: The small workhorse of evolutionary studies</title><author>Desalle, Rob ; Schierwater, Bernd ; Hadrys, Heike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-4eea42249b7a3e016f0cc26d952538d193f721d3c89552c684b3ae6a64a3a4e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>DNA Barcoding, Taxonomic</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Evolution, Molecular</topic><topic>Genetics, Population</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Hominidae - genetics</topic><topic>Humans</topic><topic>Phylogeny</topic><topic>Phylogeography</topic><topic>Selection, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desalle, Rob</creatorcontrib><creatorcontrib>Schierwater, Bernd</creatorcontrib><creatorcontrib>Hadrys, Heike</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Frontiers in bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desalle, Rob</au><au>Schierwater, Bernd</au><au>Hadrys, Heike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MtDNA: The small workhorse of evolutionary studies</atitle><jtitle>Frontiers in bioscience</jtitle><addtitle>Front Biosci (Landmark Ed)</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>22</volume><issue>5</issue><spage>873</spage><epage>887</epage><pages>873-887</pages><artnum>4522</artnum><issn>1093-9946</issn><eissn>2768-6698</eissn><eissn>1093-4715</eissn><abstract>The double-stranded, circular mitochondrial DNA (mtDNA), which is present in all eukaryotic life forms, was initially discovered and characterized in the last century and has been widely used in evolutionary studies. 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| ispartof | Frontiers in bioscience, 2017-01, Vol.22 (5), p.873-887, Article 4522 |
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| subjects | Animals DNA Barcoding, Taxonomic DNA, Mitochondrial - genetics Evolution, Molecular Genetics, Population High-Throughput Nucleotide Sequencing Hominidae - genetics Humans Phylogeny Phylogeography Selection, Genetic |
| title | MtDNA: The small workhorse of evolutionary studies |
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