Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles

To synthesize the arginine-glycine-aspartic (RGD) functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) for siRNA delivery to induce gene silencing of cancer cells and . Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as a vector of two distinct small interfe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nanomedicine (London, England) England), 2016-12, Vol.12 (23), p.3103-3115
Hauptverfasser:	Kong, Lingdan, Wu, Yilun, Alves, Carla S, Shi, Xiangyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical materials Brain cancer Cancer therapies Cell Line, Tumor dendrimer-entrapped gold nanoparticles Dendrimers - chemistry Deoxyribonucleic acid DNA Drug Delivery Systems Drug Liberation Gene expression Gene Silencing Gene therapy Glioblastoma Gold Gold - chemistry Humans Leukemia Lymphoma Metal Nanoparticles - chemistry Mice Mice, Inbred BALB C Mice, Nude Nanoparticles Oligopeptides - chemistry Particle Size Polyethylene glycol Polyethylene Glycols - chemistry Protein expression Proteins Ratios RGD peptide RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry siRNA Stem cells Transfection Vascular endothelial growth factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!