Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles
To synthesize the arginine-glycine-aspartic (RGD) functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) for siRNA delivery to induce gene silencing of cancer cells and . Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as a vector of two distinct small interfe...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2016-12, Vol.12 (23), p.3103-3115 |
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| container_title | Nanomedicine (London, England) |
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| creator | Kong, Lingdan Wu, Yilun Alves, Carla S Shi, Xiangyang |
| description | To synthesize the arginine-glycine-aspartic (RGD) functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) for siRNA delivery to induce gene silencing of cancer cells
and
.
Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as a vector of two distinct small interfering RNAs (siRNAs) (VEGFvascular endothelial growth factor siRNA and B-cell lymphoma/leukemia-2 siRNA), and the physicochemical properties, cytocompatibility and transfection efficiency of Au DENP/siRNA polyplexes were characterized.
The Au DENP/siRNA polyplexes with good cytocompatibility and highly efficient transfection capacity can be used for the transfection of siRNAs.
The developed functional RGD-modified Au DENPs may be used for efficient gene therapy of different types of cancer. |
| doi_str_mv | 10.2217/nnm-2016-0240 |
| format | Article |
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and
.
Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as a vector of two distinct small interfering RNAs (siRNAs) (VEGFvascular endothelial growth factor siRNA and B-cell lymphoma/leukemia-2 siRNA), and the physicochemical properties, cytocompatibility and transfection efficiency of Au DENP/siRNA polyplexes were characterized.
The Au DENP/siRNA polyplexes with good cytocompatibility and highly efficient transfection capacity can be used for the transfection of siRNAs.
The developed functional RGD-modified Au DENPs may be used for efficient gene therapy of different types of cancer.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2016-0240</identifier><identifier>PMID: 27809656</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Animals ; Biomedical materials ; Brain cancer ; Cancer therapies ; Cell Line, Tumor ; dendrimer-entrapped gold nanoparticles ; Dendrimers - chemistry ; Deoxyribonucleic acid ; DNA ; Drug Delivery Systems ; Drug Liberation ; Gene expression ; Gene Silencing ; Gene therapy ; Glioblastoma ; Gold ; Gold - chemistry ; Humans ; Leukemia ; Lymphoma ; Metal Nanoparticles - chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles ; Oligopeptides - chemistry ; Particle Size ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Protein expression ; Proteins ; Ratios ; RGD peptide ; RNA, Small Interfering - administration & dosage ; RNA, Small Interfering - chemistry ; siRNA ; Stem cells ; Transfection ; Vascular endothelial growth factor</subject><ispartof>Nanomedicine (London, England), 2016-12, Vol.12 (23), p.3103-3115</ispartof><rights>Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Dec 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-7929965e835620c7eb93589010b9767fad3e6f0b3cf213a7fc543d3f45729da93</citedby><cites>FETCH-LOGICAL-c371t-7929965e835620c7eb93589010b9767fad3e6f0b3cf213a7fc543d3f45729da93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27809656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Lingdan</creatorcontrib><creatorcontrib>Wu, Yilun</creatorcontrib><creatorcontrib>Alves, Carla S</creatorcontrib><creatorcontrib>Shi, Xiangyang</creatorcontrib><title>Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>To synthesize the arginine-glycine-aspartic (RGD) functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) for siRNA delivery to induce gene silencing of cancer cells
and
.
Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as a vector of two distinct small interfering RNAs (siRNAs) (VEGFvascular endothelial growth factor siRNA and B-cell lymphoma/leukemia-2 siRNA), and the physicochemical properties, cytocompatibility and transfection efficiency of Au DENP/siRNA polyplexes were characterized.
The Au DENP/siRNA polyplexes with good cytocompatibility and highly efficient transfection capacity can be used for the transfection of siRNAs.
The developed functional RGD-modified Au DENPs may be used for efficient gene therapy of different types of cancer.</description><subject>Animals</subject><subject>Biomedical materials</subject><subject>Brain cancer</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>dendrimer-entrapped gold nanoparticles</subject><subject>Dendrimers - chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Gene expression</subject><subject>Gene Silencing</subject><subject>Gene therapy</subject><subject>Glioblastoma</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Lymphoma</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Nanoparticles</subject><subject>Oligopeptides - chemistry</subject><subject>Particle Size</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Ratios</subject><subject>RGD peptide</subject><subject>RNA, Small Interfering - administration & dosage</subject><subject>RNA, Small Interfering - chemistry</subject><subject>siRNA</subject><subject>Stem cells</subject><subject>Transfection</subject><subject>Vascular endothelial growth factor</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUtrFTEYQAdRbK0u3UrAjZtoHncmybKU-oCiILoOmcyXa0omGfMQCv54M97qQnCVBE4O38cZhueUvGaMijcxrpgROmHCDuTBcE7FQeJJTfzh7zvHo5TqbHhSyi0ho2SUPB7OmJBETeN0Pvy8ds5bD7GiBYL_AfkOJYfqN8hmg1a9RcV__niJfKwJHYNPczClptUgCyEU1IqPR7S2UL1r0VafogndFZfsV8i4m7tpgwUdU1hQNDFtJndvgPJ0eORMKPDs_rwYvr69_nL1Ht98evfh6vIGWy5oxUIx1acFyceJEStgVnyUilAyKzEJZxYOkyMzt45RboSz44Ev3B1GwdRiFL8YXp28W07fG5SqV1_28U2E1Iqmkk-C05HJjr78B71NLfeVimac0ZHTPkun8ImyOZWSwemtb2vynaZE71l0z6L3LHrP0vkX99Y2r7D8pf906IA6Aa7VlqHsRSzo06v_6Iki_Ef-C2JVne4</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Kong, Lingdan</creator><creator>Wu, Yilun</creator><creator>Alves, Carla S</creator><creator>Shi, Xiangyang</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles</title><author>Kong, Lingdan ; Wu, Yilun ; Alves, Carla S ; Shi, Xiangyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-7929965e835620c7eb93589010b9767fad3e6f0b3cf213a7fc543d3f45729da93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biomedical materials</topic><topic>Brain cancer</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>dendrimer-entrapped gold nanoparticles</topic><topic>Dendrimers - chemistry</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug Delivery Systems</topic><topic>Drug Liberation</topic><topic>Gene expression</topic><topic>Gene Silencing</topic><topic>Gene therapy</topic><topic>Glioblastoma</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Lymphoma</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Nanoparticles</topic><topic>Oligopeptides - chemistry</topic><topic>Particle Size</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Ratios</topic><topic>RGD peptide</topic><topic>RNA, Small Interfering - administration & dosage</topic><topic>RNA, Small Interfering - chemistry</topic><topic>siRNA</topic><topic>Stem cells</topic><topic>Transfection</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Lingdan</creatorcontrib><creatorcontrib>Wu, Yilun</creatorcontrib><creatorcontrib>Alves, Carla S</creatorcontrib><creatorcontrib>Shi, Xiangyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Lingdan</au><au>Wu, Yilun</au><au>Alves, Carla S</au><au>Shi, Xiangyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>12</volume><issue>23</issue><spage>3103</spage><epage>3115</epage><pages>3103-3115</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>To synthesize the arginine-glycine-aspartic (RGD) functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) for siRNA delivery to induce gene silencing of cancer cells
and
.
Au DENPs modified with RGD peptide via a polyethylene glycol spacer were used as a vector of two distinct small interfering RNAs (siRNAs) (VEGFvascular endothelial growth factor siRNA and B-cell lymphoma/leukemia-2 siRNA), and the physicochemical properties, cytocompatibility and transfection efficiency of Au DENP/siRNA polyplexes were characterized.
The Au DENP/siRNA polyplexes with good cytocompatibility and highly efficient transfection capacity can be used for the transfection of siRNAs.
The developed functional RGD-modified Au DENPs may be used for efficient gene therapy of different types of cancer.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>27809656</pmid><doi>10.2217/nnm-2016-0240</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Biomedical materials Brain cancer Cancer therapies Cell Line, Tumor dendrimer-entrapped gold nanoparticles Dendrimers - chemistry Deoxyribonucleic acid DNA Drug Delivery Systems Drug Liberation Gene expression Gene Silencing Gene therapy Glioblastoma Gold Gold - chemistry Humans Leukemia Lymphoma Metal Nanoparticles - chemistry Mice Mice, Inbred BALB C Mice, Nude Nanoparticles Oligopeptides - chemistry Particle Size Polyethylene glycol Polyethylene Glycols - chemistry Protein expression Proteins Ratios RGD peptide RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry siRNA Stem cells Transfection Vascular endothelial growth factor |
| title | Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles |
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