Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases

Epithelial-mesenchymal transition (EMT) is a plastic transition in tumor progression during which cancer cells undergo dramatic changes acquiring highly invasive properties. Transforming growth factor-β (TGF-β) is an inducer of EMT in epithelial cells and is obligatory for acquiring invasive phenoty...

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Veröffentlicht in:	Tumor biology 2016-10, Vol.37 (10), p.14025-14034
Hauptverfasser:	Baruah, Meghna M., Khandwekar, Anand P., Sharma, Neeti
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Apoptosis - drug effects Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cadherins - genetics Cadherins - metabolism Cancer Cancer Research Cancer therapies Cell adhesion & migration Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Epithelial-Mesenchymal Transition - drug effects Humans Immunoenzyme Techniques Male Original Article Phytochemicals Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Quercetin - pharmacology Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal transduction Signal Transduction - drug effects Transforming Growth Factor beta1 - pharmacology Tumor Cells, Cultured Wnt Proteins - genetics Wnt Proteins - metabolism Xenograft Model Antitumor Assays
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