Integrated Proteomic Pipeline Using Multiple Search Engines for a Proteogenomic Study with a Controlled Protein False Discovery Rate

In the Chromosome-Centric Human Proteome Project (C-HPP), false-positive identification by peptide spectrum matches (PSMs) after database searches is a major issue for proteogenomic studies using liquid-chromatography and mass-spectrometry-based large proteomic profiling. Here we developed a simple...

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Veröffentlicht in:	Journal of proteome research 2016-11, Vol.15 (11), p.4082-4090
Hauptverfasser:	Park, Gun Wook, Hwang, Heeyoun, Kim, Kwang Hoe, Lee, Ju Yeon, Lee, Hyun Kyoung, Park, Ji Yeong, Ji, Eun Sun, Park, Sung-Kyu Robin, Yates, John R, Kwon, Kyung-Hoon, Park, Young Mok, Lee, Hyoung-Joo, Paik, Young-Ki, Kim, Jin Young, Yoo, Jong Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Computational Biology - methods Databases, Protein False Positive Reactions Hippocampus - chemistry Humans Mass Spectrometry - methods Proteogenomics - methods Proteomics - methods Search Engine
Online-Zugang:	Volltext
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