Kinetic studies on the reaction of cob(II)alamin with hypochlorous acid: Evidence for one electron oxidation of the metal center and corrin ring destruction

Kinetic and mechanistic studies on the reaction of a major intracellular vitamin B12 form, cob(II)alamin (Cbl(II)), with hypochlorous acid/hypochlorite (HOCl/OCl−) have been carried out. Cbl(II) (Co(II)) is rapidly oxidized by HOCl to predominately aquacobalamin/hydroxycobalamin (Cbl(III), Co(III))...

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Veröffentlicht in:	Journal of inorganic biochemistry 2016-10, Vol.163, p.81-87
Hauptverfasser:	Dassanayake, Rohan S., Farhath, Mohamed M., Shelley, Jacob T., Basu, Soumitra, Brasch, Nicola E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cobalamins Corrin ring destruction Electrons Hypochlorous Acid - chemistry Hypochlorous acid, kinetics Kinetics Oxidation-Reduction Serum Albumin, Bovine - chemistry Vitamin B 12 - chemistry Vitamin B12
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