Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression

Double‐stranded DNA breaks induce serine phosphorylation of histone H2A.X, producing γ‐H2A.X foci that are then recognized by DNA damage response pathway proteins. Formation of γ‐H2A.X is therefore critical for the repair of DNA double‐stranded breaks and maintenance of genomic stability, and defect...

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Veröffentlicht in:	The FEBS journal 2016-12, Vol.283 (24), p.4462-4473
Hauptverfasser:	Liu, Yan, Long, Yue‐Hong, Wang, Shu‐Qing, Li, Yu‐Feng, Zhang, Jing‐Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Deoxyribonucleic acid DNA DNA damage DSBs EYA2 H2A.X Phosphorylation Tumorigenesis
Online-Zugang:	Volltext
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