Comparison of the Tolerability of Diclofenac and Nepafenac
Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the prevention and treatment of inflammation and pain following cataract surgery. Preservative-free diclofenac and nepafenac drops are commonly used ophthalmic NSAIDs. The purpose of this study was to compare the tolerability...
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| Veröffentlicht in: | Journal of ocular pharmacology and therapeutics 2016-11, Vol.32 (9), p.601-605 |
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| container_title | Journal of ocular pharmacology and therapeutics |
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| creator | Achiron, Asaf Karmona, Lily Mimouni, Michael Gershoni, Assaf Dzhanov, Yana Gur, Zvi Burgansky, Zvia |
| description | Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the prevention and treatment of inflammation and pain following cataract surgery. Preservative-free diclofenac and nepafenac drops are commonly used ophthalmic NSAIDs. The purpose of this study was to compare the tolerability of diclofenac to that of nepafenac.
In this prospective patient-blinded study, consecutive patients undergoing cataract surgery were included. One drop of nepafenac 0.1% and diclofenac sodium 0.1% were instilled in the right and left eyes, respectively, one immediately after the other, 1 day before surgery. Visual analog scale (scale 0-10) was used to measure patient discomfort, itching, burning, and pain at 1 second (s), 15 s, 1 minute (min), and 5 min postadministration.
Overall, 44 eyes of 22 patients were included in this study. Diclofenac and nepafenac had high and similar tolerability at all time points with no significant difference regarding all aspects of tolerability. A vast majority of patients (72%) did not prefer 1 drop over the other in terms of overall comfort.
Both diclofenac and nepafenac seem to have similar high tolerability. Diclofenac may be an affordable alternative to nepafenac and therefore should be considered by prescribing physicians, specifically in preoperative cataract patients. |
| doi_str_mv | 10.1089/jop.2016.0057 |
| format | Article |
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In this prospective patient-blinded study, consecutive patients undergoing cataract surgery were included. One drop of nepafenac 0.1% and diclofenac sodium 0.1% were instilled in the right and left eyes, respectively, one immediately after the other, 1 day before surgery. Visual analog scale (scale 0-10) was used to measure patient discomfort, itching, burning, and pain at 1 second (s), 15 s, 1 minute (min), and 5 min postadministration.
Overall, 44 eyes of 22 patients were included in this study. Diclofenac and nepafenac had high and similar tolerability at all time points with no significant difference regarding all aspects of tolerability. A vast majority of patients (72%) did not prefer 1 drop over the other in terms of overall comfort.
Both diclofenac and nepafenac seem to have similar high tolerability. Diclofenac may be an affordable alternative to nepafenac and therefore should be considered by prescribing physicians, specifically in preoperative cataract patients.</description><identifier>ISSN: 1080-7683</identifier><identifier>EISSN: 1557-7732</identifier><identifier>DOI: 10.1089/jop.2016.0057</identifier><identifier>PMID: 27513223</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Topical ; Aged ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Benzeneacetamides - administration & dosage ; Benzeneacetamides - adverse effects ; Benzeneacetamides - therapeutic use ; Diclofenac - administration & dosage ; Diclofenac - adverse effects ; Diclofenac - therapeutic use ; Double-Blind Method ; Female ; Humans ; Inflammation - drug therapy ; Inflammation - surgery ; Male ; Molecular Structure ; Ophthalmic Solutions - administration & dosage ; Ophthalmic Solutions - adverse effects ; Ophthalmic Solutions - therapeutic use ; Pain Measurement ; Pain, Postoperative - drug therapy ; Pain, Postoperative - surgery ; Phenylacetates - administration & dosage ; Phenylacetates - adverse effects ; Phenylacetates - therapeutic use ; Prospective Studies ; Visual Analog Scale</subject><ispartof>Journal of ocular pharmacology and therapeutics, 2016-11, Vol.32 (9), p.601-605</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-61c56a86e3790d4dd3fd4b700c76f70c33828610f40931c67e49346a539fcbfe3</citedby><cites>FETCH-LOGICAL-c319t-61c56a86e3790d4dd3fd4b700c76f70c33828610f40931c67e49346a539fcbfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27513223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Achiron, Asaf</creatorcontrib><creatorcontrib>Karmona, Lily</creatorcontrib><creatorcontrib>Mimouni, Michael</creatorcontrib><creatorcontrib>Gershoni, Assaf</creatorcontrib><creatorcontrib>Dzhanov, Yana</creatorcontrib><creatorcontrib>Gur, Zvi</creatorcontrib><creatorcontrib>Burgansky, Zvia</creatorcontrib><title>Comparison of the Tolerability of Diclofenac and Nepafenac</title><title>Journal of ocular pharmacology and therapeutics</title><addtitle>J Ocul Pharmacol Ther</addtitle><description>Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the prevention and treatment of inflammation and pain following cataract surgery. Preservative-free diclofenac and nepafenac drops are commonly used ophthalmic NSAIDs. The purpose of this study was to compare the tolerability of diclofenac to that of nepafenac.
In this prospective patient-blinded study, consecutive patients undergoing cataract surgery were included. One drop of nepafenac 0.1% and diclofenac sodium 0.1% were instilled in the right and left eyes, respectively, one immediately after the other, 1 day before surgery. Visual analog scale (scale 0-10) was used to measure patient discomfort, itching, burning, and pain at 1 second (s), 15 s, 1 minute (min), and 5 min postadministration.
Overall, 44 eyes of 22 patients were included in this study. Diclofenac and nepafenac had high and similar tolerability at all time points with no significant difference regarding all aspects of tolerability. A vast majority of patients (72%) did not prefer 1 drop over the other in terms of overall comfort.
Both diclofenac and nepafenac seem to have similar high tolerability. Diclofenac may be an affordable alternative to nepafenac and therefore should be considered by prescribing physicians, specifically in preoperative cataract patients.</description><subject>Administration, Topical</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Benzeneacetamides - administration & dosage</subject><subject>Benzeneacetamides - adverse effects</subject><subject>Benzeneacetamides - therapeutic use</subject><subject>Diclofenac - administration & dosage</subject><subject>Diclofenac - adverse effects</subject><subject>Diclofenac - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - surgery</subject><subject>Male</subject><subject>Molecular Structure</subject><subject>Ophthalmic Solutions - administration & dosage</subject><subject>Ophthalmic Solutions - adverse effects</subject><subject>Ophthalmic Solutions - therapeutic use</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - surgery</subject><subject>Phenylacetates - administration & dosage</subject><subject>Phenylacetates - adverse effects</subject><subject>Phenylacetates - therapeutic use</subject><subject>Prospective Studies</subject><subject>Visual Analog Scale</subject><issn>1080-7683</issn><issn>1557-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAQhi0EoqUwsqKMLClnX2I7bKh8ShUsZbYcxxapkjjY6dB_T0IL0929evRK9xByTWFJQRZ3W98vGVC-BMjFCZnTPBepEMhOxx0kpIJLnJGLGLcAFIHTczJjIqfIGM7J_cq3vQ519F3iXTJ82WTjGxt0WTf1sJ-yx9o03tlOm0R3VfJue_17XZIzp5tor45zQT6fnzar13T98fK2elinBmkxpJyanGvJLYoCqqyq0FVZKQCM4E6AQZRMcgougwKp4cJmBWZc51g4UzqLC3J76O2D_97ZOKi2jsY2je6s30VFJXLBBB9fWpD0gJrgYwzWqT7UrQ57RUFNutSoS0261KRr5G-O1buytdU__ecHfwCbFGQo</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Achiron, Asaf</creator><creator>Karmona, Lily</creator><creator>Mimouni, Michael</creator><creator>Gershoni, Assaf</creator><creator>Dzhanov, Yana</creator><creator>Gur, Zvi</creator><creator>Burgansky, Zvia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Comparison of the Tolerability of Diclofenac and Nepafenac</title><author>Achiron, Asaf ; 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Preservative-free diclofenac and nepafenac drops are commonly used ophthalmic NSAIDs. The purpose of this study was to compare the tolerability of diclofenac to that of nepafenac.
In this prospective patient-blinded study, consecutive patients undergoing cataract surgery were included. One drop of nepafenac 0.1% and diclofenac sodium 0.1% were instilled in the right and left eyes, respectively, one immediately after the other, 1 day before surgery. Visual analog scale (scale 0-10) was used to measure patient discomfort, itching, burning, and pain at 1 second (s), 15 s, 1 minute (min), and 5 min postadministration.
Overall, 44 eyes of 22 patients were included in this study. Diclofenac and nepafenac had high and similar tolerability at all time points with no significant difference regarding all aspects of tolerability. A vast majority of patients (72%) did not prefer 1 drop over the other in terms of overall comfort.
Both diclofenac and nepafenac seem to have similar high tolerability. Diclofenac may be an affordable alternative to nepafenac and therefore should be considered by prescribing physicians, specifically in preoperative cataract patients.</abstract><cop>United States</cop><pmid>27513223</pmid><doi>10.1089/jop.2016.0057</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Topical Aged Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Benzeneacetamides - administration & dosage Benzeneacetamides - adverse effects Benzeneacetamides - therapeutic use Diclofenac - administration & dosage Diclofenac - adverse effects Diclofenac - therapeutic use Double-Blind Method Female Humans Inflammation - drug therapy Inflammation - surgery Male Molecular Structure Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - adverse effects Ophthalmic Solutions - therapeutic use Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - surgery Phenylacetates - administration & dosage Phenylacetates - adverse effects Phenylacetates - therapeutic use Prospective Studies Visual Analog Scale |
| title | Comparison of the Tolerability of Diclofenac and Nepafenac |
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