Global left atrial failure in heart failure
The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, L...
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| Veröffentlicht in: | European journal of heart failure 2016-11, Vol.18 (11), p.1307-1320 |
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| container_title | European journal of heart failure |
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| creator | Triposkiadis, Filippos Pieske, Burkert Butler, Javed Parissis, John Giamouzis, Gregory Skoularigis, John Brutsaert, Dirk Boudoulas, Harisios |
| description | The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing‐synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure. |
| doi_str_mv | 10.1002/ejhf.645 |
| format | Article |
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However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing‐synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1002/ejhf.645</identifier><identifier>PMID: 27813305</identifier><language>eng</language><publisher>Oxford, UK: John Wiley & Sons, Ltd</publisher><subject>Atrial Fibrillation - etiology ; Atrial Fibrillation - physiopathology ; Atrial Function, Left ; Atrial Natriuretic Factor - metabolism ; Dilatation ; Heart Atria - metabolism ; Heart Atria - physiopathology ; Heart failure ; Heart Failure - metabolism ; Heart Failure - physiopathology ; Humans ; Left atrium ; Natriuretic peptide ; Sympathetic Nervous System - physiopathology ; Vasoconstriction ; Vasopressins - metabolism ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>European journal of heart failure, 2016-11, Vol.18 (11), p.1307-1320</ispartof><rights>2016 The Authors. © 2016 European Society of Cardiology</rights><rights>2016 The Authors. European Journal of Heart Failure © 2016 European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5295-c6e23de9f2439deaa88003c37c924215ef9c77c3b93f2c510c82f7eabfa217ba3</citedby><cites>FETCH-LOGICAL-c5295-c6e23de9f2439deaa88003c37c924215ef9c77c3b93f2c510c82f7eabfa217ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejhf.645$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejhf.645$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27813305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Triposkiadis, Filippos</creatorcontrib><creatorcontrib>Pieske, Burkert</creatorcontrib><creatorcontrib>Butler, Javed</creatorcontrib><creatorcontrib>Parissis, John</creatorcontrib><creatorcontrib>Giamouzis, Gregory</creatorcontrib><creatorcontrib>Skoularigis, John</creatorcontrib><creatorcontrib>Brutsaert, Dirk</creatorcontrib><creatorcontrib>Boudoulas, Harisios</creatorcontrib><title>Global left atrial failure in heart failure</title><title>European journal of heart failure</title><addtitle>Eur J Heart Fail</addtitle><description>The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing‐synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.</description><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Function, Left</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Dilatation</subject><subject>Heart Atria - metabolism</subject><subject>Heart Atria - physiopathology</subject><subject>Heart failure</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Left atrium</subject><subject>Natriuretic peptide</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Vasoconstriction</subject><subject>Vasopressins - metabolism</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LwzAYh4Mobk7Bv0B6FKQzH22THGVsnTrmQcVjSLM3rDNbZ9Ki--_t2IcnT--Pl4fn8CB0TXCfYEzvYTG3_SxJT1CXCC5jLJLktN1MiFiKhHbQRQgLjAlv6XPUoVwQxnDaRXe5qwrtIge2jnTty3ZbXbrGQ1SuojloXx8el-jMahfgan976H00fBuM48lL_jh4mMQmpTKNTQaUzUBamjA5A62FwJgZxo2kCSUpWGk4N6yQzFKTEmwEtRx0YTUlvNCsh2533rWvvhoItVqWwYBzegVVExQRLOM0E5L9ocZXIXiwau3LpfYbRbDaplHbNKpN06I3e2tTLGF2BA8tWiDeAd-lg82_IjV8Go92wj1fhhp-jrz2nyrjjKfqY5orJifPg9epUJT9AvNnewc</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Triposkiadis, Filippos</creator><creator>Pieske, Burkert</creator><creator>Butler, Javed</creator><creator>Parissis, John</creator><creator>Giamouzis, Gregory</creator><creator>Skoularigis, John</creator><creator>Brutsaert, Dirk</creator><creator>Boudoulas, Harisios</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Global left atrial failure in heart failure</title><author>Triposkiadis, Filippos ; 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However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing‐synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.</abstract><cop>Oxford, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>27813305</pmid><doi>10.1002/ejhf.645</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of heart failure, 2016-11, Vol.18 (11), p.1307-1320 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
| subjects | Atrial Fibrillation - etiology Atrial Fibrillation - physiopathology Atrial Function, Left Atrial Natriuretic Factor - metabolism Dilatation Heart Atria - metabolism Heart Atria - physiopathology Heart failure Heart Failure - metabolism Heart Failure - physiopathology Humans Left atrium Natriuretic peptide Sympathetic Nervous System - physiopathology Vasoconstriction Vasopressins - metabolism Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - physiopathology |
| title | Global left atrial failure in heart failure |
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