Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva
Highlights • Type I plasminogen deficiency is an uncommon chronic inflammation of mucous membranes. • Fibrin clearance is disturbed in this entity. • Plasmin(ogen)-independent enzymatic mechanisms for fibrin clearance were discussed. • Alternative enzymatic fibrin clearance through elastase, MMP-3,...
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| Veröffentlicht in: | Archives of oral biology 2016-12, Vol.72, p.75-86 |
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| container_title | Archives of oral biology |
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| creator | Waschulewski, Idil Kurtulus Gökbuget, Aslan Y Christiansen, Nina M Ziegler, Maike Schuster, Volker Wahl, Gerhard Götz, Werner |
| description | Highlights • Type I plasminogen deficiency is an uncommon chronic inflammation of mucous membranes. • Fibrin clearance is disturbed in this entity. • Plasmin(ogen)-independent enzymatic mechanisms for fibrin clearance were discussed. • Alternative enzymatic fibrin clearance through elastase, MMP-3, MMP-7 have been shown in this study. • Local application of plasminogen is discussed as therapeutic approach. • The exact pathomechanism of this entity needs to be determined. |
| doi_str_mv | 10.1016/j.archoralbio.2016.07.013 |
| format | Article |
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| subjects | Adolescent Advanced Basic Science Case-Control Studies Child Conjunctivitis - pathology Dentistry Enzyme-Linked Immunosorbent Assay Female Gingiva Gingiva - enzymology Gingiva - microbiology Gingiva - pathology Gingivitis - enzymology Gingivitis - microbiology Gingivitis - pathology Humans Immunohistochemistry Male Periodontitis Periodontitis - enzymology Periodontitis - microbiology Periodontitis - pathology Plasminogen Plasminogen - deficiency Polymerase Chain Reaction Skin Diseases, Genetic - pathology Type I plasminogen deficiency Young Adult |
| title | Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva |
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