Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of Mucopolysaccharidosis type II (MPS II) disorder

Peripheral blood was collected from a 39-year-old unaffected female carrier of an X-linked recessive mutation of Iduronate 2-sulfatase gene (NM_000202.7(IDS):c.85C>T) causing MPS II (OMIM 309900). Peripheral blood mononuclear cells (PBMCs) were reprogrammed by lentiviral delivery of a self-silenc...

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Veröffentlicht in:	Stem cell research 2016-11, Vol.17 (3), p.514-516
Hauptverfasser:	Varga, Eszter, Nemes, Csilla, Kovács, Eszter, Bock, István, Varga, Norbert, Fehér, Anita, Dinnyés, András, Kobolák, Julianna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Base Sequence Cell Differentiation Cell Line Cellular Reprogramming Embryoid Bodies - cytology Embryoid Bodies - metabolism Female Genetic Vectors - genetics Genetic Vectors - metabolism Glycoproteins - genetics Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Karyotype Lentivirus - genetics Leukocytes, Mononuclear - cytology Microscopy, Fluorescence Mucopolysaccharidosis II - genetics Mucopolysaccharidosis II - pathology Polymorphism, Single Nucleotide Sequence Analysis, DNA Transcription Factors - genetics Transcription Factors - metabolism
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