Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells

Dimethylsulfoxide (DMSO) induces cellular differentiation and expression of drug metabolic enzymes in the human liver cell line HepaRG; however, DMSO also induces cell death and interferes with cellular activities. The aim of this study was to examine whether overexpression of the constitutive andro...

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Veröffentlicht in:	Drug metabolism and disposition 2017-01, Vol.45 (1), p.56-67
Hauptverfasser:	van der Mark, Vincent A, Rudi de Waart, D, Shevchenko, Valery, Elferink, Ronald P J Oude, Chamuleau, Robert A F M, Hoekstra, Ruurdtje
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Culture Techniques Cell Differentiation - drug effects Cell Line, Tumor Culture Media - chemistry Dimethyl Sulfoxide - pharmacology Drug Evaluation, Preclinical Genetic Vectors Humans Lentivirus - genetics Liver - metabolism Metabolic Detoxication, Phase I Metabolic Detoxication, Phase II Models, Biological Pharmaceutical Preparations - metabolism Receptors, Cytoplasmic and Nuclear - genetics
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