Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2017-12, Vol.32 (1), p.51-59
Hauptverfasser:	D'Ascenzio, Melissa, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, Florio, Rosalba, Mollica, Adriano, Ceruso, Mariangela, Akdemir, Atilla, Sobolev, Anatoly P., Supuran, Claudiu T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Cancer Cancer-related isoforms Carbonic anhydrase I Carbonic anhydrase II Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - drug effects Chemistry Computer applications Dihydrofolate reductase Enzymes Humans Isoforms Metastasis Molecular Structure Neoplasms - enzymology Pharmaceutical sciences Pharmacy Protein Isoforms - drug effects Saccharin Saccharin - chemistry secondary sulphonamides selective carbonic anhydrase inhibitors Spectrum Analysis - methods Sulfonamides Sulfonamides - chemistry
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