Designer Histone Complexes: Controlling Protein–DNA Interactions with Protein Charge as an “All-or-None” Digital Switch

An artificial histone is synthesized that functions as a DNA–protein digital switch, where DNA binding is all or none, controlled by a sharp threshold of protein charge. A non-DNA-binding protein, glucose oxidase (GOx), was chemically modified by attaching an increasing number of triethylenetetramin...

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Veröffentlicht in:	The journal of physical chemistry. B 2016-11, Vol.120 (46), p.11880-11887
Hauptverfasser:	Baveghems, Clive L, Pattammattel, Ajith, Kumar, Challa V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle DNA - chemistry DNA - metabolism Electrophoresis, Agar Gel Glucose Oxidase - chemistry Glucose Oxidase - metabolism Histones - chemistry Histones - metabolism Static Electricity Thermodynamics
Online-Zugang:	Volltext
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