Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery
Background Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant orga...
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| Veröffentlicht in: | Annals of surgical oncology 2017-04, Vol.24 (4), p.1135-1142 |
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| container_title | Annals of surgical oncology |
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| creator | Nojiri, Takashi Hamasaki, Toshimitsu Inoue, Masayoshi Shintani, Yasushi Takeuchi, Yukiyasu Maeda, Hajime Okumura, Meinoshin |
| description | Background
Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in early cancer recurrence. We investigated the impact of postoperative cardiopulmonary complications on cancer recurrence following lung cancer surgery.
Methods
From a prospective database of 675 consecutive patients who underwent curative surgery for lung cancer between 2007 and 2012, the incidence of postoperative cardiopulmonary complications, white blood cell counts, and C-reactive protein levels were evaluated in the acute phase after surgery. Four patients had both cardiovascular and respiratory complications. The remaining 671 patients were divided into 3 groups: patients without cardiopulmonary complications; those with cardiovascular complications; and those with respiratory complications. The incidence of cancer recurrence was compared among the three groups.
Results
Postoperative cardiovascular or respiratory complications were identified in 94 (14%) or 25 (4%) patients, respectively. Postoperative white blood cell counts and C-reactive protein levels were significantly higher in those with postoperative respiratory complications than in those without. There was a significantly higher incidence of cancer recurrence in those with postoperative respiratory complications than in those without (48.0 vs. 16.8%;
p
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| doi_str_mv | 10.1245/s10434-016-5655-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835685254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835685254</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-6845a07de93a93c0acbf5b2af1c7147fbec7ad278a7071002f73c052f84b52fe3</originalsourceid><addsrcrecordid>eNp1kU1LxDAQhoMo7rr6A7xIwIuXapLmq0cprgoLiq7nkGbTpUvb1KRV9t-bpauI4GUymTzzZpgXgHOMrjGh7CZgRFOaIMwTxhlL5AGYYhYrlEt8GHPEZZIRzibgJIQNQlikiB2DCRFCMs7RFBQL166TpfUNfGw6bXroSvjsQu8663VffViYu6arKxMvrg3QtTDXrbEevlgzeG9jDueurt1n1a7hYohhD7wOfm399hQclboO9mx_zsDb_G6ZPySLp_vH_HaRGJrKPuGSMo3EymapzlKDtClKVhBdYiMwFWVhjdArIqQWSGCESCkixUgpaRGjTWfgatTtvHsfbOhVUwVj61q31g1BYZkyLhlhNKKXf9CNG3wbp4uUoJxITLJI4ZEy3oXgbak6XzXabxVGameAGg1Q0QC1M0DJ2HOxVx6Kxq5-Or43HgEyAiE-tXE_v77-V_ULl5uQoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1874628129</pqid></control><display><type>article</type><title>Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery</title><source>MEDLINE</source><source>SpringerLink</source><creator>Nojiri, Takashi ; Hamasaki, Toshimitsu ; Inoue, Masayoshi ; Shintani, Yasushi ; Takeuchi, Yukiyasu ; Maeda, Hajime ; Okumura, Meinoshin</creator><creatorcontrib>Nojiri, Takashi ; Hamasaki, Toshimitsu ; Inoue, Masayoshi ; Shintani, Yasushi ; Takeuchi, Yukiyasu ; Maeda, Hajime ; Okumura, Meinoshin</creatorcontrib><description>Background
Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in early cancer recurrence. We investigated the impact of postoperative cardiopulmonary complications on cancer recurrence following lung cancer surgery.
Methods
From a prospective database of 675 consecutive patients who underwent curative surgery for lung cancer between 2007 and 2012, the incidence of postoperative cardiopulmonary complications, white blood cell counts, and C-reactive protein levels were evaluated in the acute phase after surgery. Four patients had both cardiovascular and respiratory complications. The remaining 671 patients were divided into 3 groups: patients without cardiopulmonary complications; those with cardiovascular complications; and those with respiratory complications. The incidence of cancer recurrence was compared among the three groups.
Results
Postoperative cardiovascular or respiratory complications were identified in 94 (14%) or 25 (4%) patients, respectively. Postoperative white blood cell counts and C-reactive protein levels were significantly higher in those with postoperative respiratory complications than in those without. There was a significantly higher incidence of cancer recurrence in those with postoperative respiratory complications than in those without (48.0 vs. 16.8%;
p
< 0.0001). Multiple regression analysis adjusted for age, sex, and pathological staging showed that the incidence of postoperative respiratory complications was a significant predictor of cancer recurrence.
Conclusions
The presence of respiratory complications following lung cancer surgery was a significant predictor of cancer recurrence.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-016-5655-8</identifier><identifier>PMID: 27785660</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acute-Phase Reaction - blood ; Acute-Phase Reaction - etiology ; Aged ; C-Reactive Protein - metabolism ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Disease-Free Survival ; Female ; Humans ; Incidence ; Leukocyte Count ; Lung cancer ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local - epidemiology ; Oncology ; Postoperative Complications - blood ; Postoperative Complications - etiology ; Postoperative Period ; Respiratory Tract Diseases - blood ; Respiratory Tract Diseases - etiology ; Surgery ; Surgical Oncology ; Thoracic Oncology ; Time Factors</subject><ispartof>Annals of surgical oncology, 2017-04, Vol.24 (4), p.1135-1142</ispartof><rights>Society of Surgical Oncology 2016</rights><rights>Annals of Surgical Oncology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-6845a07de93a93c0acbf5b2af1c7147fbec7ad278a7071002f73c052f84b52fe3</citedby><cites>FETCH-LOGICAL-c438t-6845a07de93a93c0acbf5b2af1c7147fbec7ad278a7071002f73c052f84b52fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-016-5655-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-016-5655-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27785660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nojiri, Takashi</creatorcontrib><creatorcontrib>Hamasaki, Toshimitsu</creatorcontrib><creatorcontrib>Inoue, Masayoshi</creatorcontrib><creatorcontrib>Shintani, Yasushi</creatorcontrib><creatorcontrib>Takeuchi, Yukiyasu</creatorcontrib><creatorcontrib>Maeda, Hajime</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><title>Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in early cancer recurrence. We investigated the impact of postoperative cardiopulmonary complications on cancer recurrence following lung cancer surgery.
Methods
From a prospective database of 675 consecutive patients who underwent curative surgery for lung cancer between 2007 and 2012, the incidence of postoperative cardiopulmonary complications, white blood cell counts, and C-reactive protein levels were evaluated in the acute phase after surgery. Four patients had both cardiovascular and respiratory complications. The remaining 671 patients were divided into 3 groups: patients without cardiopulmonary complications; those with cardiovascular complications; and those with respiratory complications. The incidence of cancer recurrence was compared among the three groups.
Results
Postoperative cardiovascular or respiratory complications were identified in 94 (14%) or 25 (4%) patients, respectively. Postoperative white blood cell counts and C-reactive protein levels were significantly higher in those with postoperative respiratory complications than in those without. There was a significantly higher incidence of cancer recurrence in those with postoperative respiratory complications than in those without (48.0 vs. 16.8%;
p
< 0.0001). Multiple regression analysis adjusted for age, sex, and pathological staging showed that the incidence of postoperative respiratory complications was a significant predictor of cancer recurrence.
Conclusions
The presence of respiratory complications following lung cancer surgery was a significant predictor of cancer recurrence.</description><subject>Acute-Phase Reaction - blood</subject><subject>Acute-Phase Reaction - etiology</subject><subject>Aged</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Leukocyte Count</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Oncology</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Period</subject><subject>Respiratory Tract Diseases - blood</subject><subject>Respiratory Tract Diseases - etiology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Thoracic Oncology</subject><subject>Time Factors</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1LxDAQhoMo7rr6A7xIwIuXapLmq0cprgoLiq7nkGbTpUvb1KRV9t-bpauI4GUymTzzZpgXgHOMrjGh7CZgRFOaIMwTxhlL5AGYYhYrlEt8GHPEZZIRzibgJIQNQlikiB2DCRFCMs7RFBQL166TpfUNfGw6bXroSvjsQu8663VffViYu6arKxMvrg3QtTDXrbEevlgzeG9jDueurt1n1a7hYohhD7wOfm399hQclboO9mx_zsDb_G6ZPySLp_vH_HaRGJrKPuGSMo3EymapzlKDtClKVhBdYiMwFWVhjdArIqQWSGCESCkixUgpaRGjTWfgatTtvHsfbOhVUwVj61q31g1BYZkyLhlhNKKXf9CNG3wbp4uUoJxITLJI4ZEy3oXgbak6XzXabxVGameAGg1Q0QC1M0DJ2HOxVx6Kxq5-Or43HgEyAiE-tXE_v77-V_ULl5uQoA</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Nojiri, Takashi</creator><creator>Hamasaki, Toshimitsu</creator><creator>Inoue, Masayoshi</creator><creator>Shintani, Yasushi</creator><creator>Takeuchi, Yukiyasu</creator><creator>Maeda, Hajime</creator><creator>Okumura, Meinoshin</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery</title><author>Nojiri, Takashi ; Hamasaki, Toshimitsu ; Inoue, Masayoshi ; Shintani, Yasushi ; Takeuchi, Yukiyasu ; Maeda, Hajime ; Okumura, Meinoshin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-6845a07de93a93c0acbf5b2af1c7147fbec7ad278a7071002f73c052f84b52fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute-Phase Reaction - blood</topic><topic>Acute-Phase Reaction - etiology</topic><topic>Aged</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Leukocyte Count</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Oncology</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Period</topic><topic>Respiratory Tract Diseases - blood</topic><topic>Respiratory Tract Diseases - etiology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Thoracic Oncology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nojiri, Takashi</creatorcontrib><creatorcontrib>Hamasaki, Toshimitsu</creatorcontrib><creatorcontrib>Inoue, Masayoshi</creatorcontrib><creatorcontrib>Shintani, Yasushi</creatorcontrib><creatorcontrib>Takeuchi, Yukiyasu</creatorcontrib><creatorcontrib>Maeda, Hajime</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nojiri, Takashi</au><au>Hamasaki, Toshimitsu</au><au>Inoue, Masayoshi</au><au>Shintani, Yasushi</au><au>Takeuchi, Yukiyasu</au><au>Maeda, Hajime</au><au>Okumura, Meinoshin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>24</volume><issue>4</issue><spage>1135</spage><epage>1142</epage><pages>1135-1142</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in early cancer recurrence. We investigated the impact of postoperative cardiopulmonary complications on cancer recurrence following lung cancer surgery.
Methods
From a prospective database of 675 consecutive patients who underwent curative surgery for lung cancer between 2007 and 2012, the incidence of postoperative cardiopulmonary complications, white blood cell counts, and C-reactive protein levels were evaluated in the acute phase after surgery. Four patients had both cardiovascular and respiratory complications. The remaining 671 patients were divided into 3 groups: patients without cardiopulmonary complications; those with cardiovascular complications; and those with respiratory complications. The incidence of cancer recurrence was compared among the three groups.
Results
Postoperative cardiovascular or respiratory complications were identified in 94 (14%) or 25 (4%) patients, respectively. Postoperative white blood cell counts and C-reactive protein levels were significantly higher in those with postoperative respiratory complications than in those without. There was a significantly higher incidence of cancer recurrence in those with postoperative respiratory complications than in those without (48.0 vs. 16.8%;
p
< 0.0001). Multiple regression analysis adjusted for age, sex, and pathological staging showed that the incidence of postoperative respiratory complications was a significant predictor of cancer recurrence.
Conclusions
The presence of respiratory complications following lung cancer surgery was a significant predictor of cancer recurrence.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27785660</pmid><doi>10.1245/s10434-016-5655-8</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2017-04, Vol.24 (4), p.1135-1142 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerLink |
| subjects | Acute-Phase Reaction - blood Acute-Phase Reaction - etiology Aged C-Reactive Protein - metabolism Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Disease-Free Survival Female Humans Incidence Leukocyte Count Lung cancer Lung Neoplasms - pathology Lung Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local - epidemiology Oncology Postoperative Complications - blood Postoperative Complications - etiology Postoperative Period Respiratory Tract Diseases - blood Respiratory Tract Diseases - etiology Surgery Surgical Oncology Thoracic Oncology Time Factors |
| title | Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery |
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