The role of variants regulating metformin transport and action in women with polycystic ovary syndrome
Variants in genes encoding metformin transport proteins and the gene are associated with metformin response. We hypothesized that these gene variants contribute to variable metformin treatment response in polycystic ovary syndrome. The discovery cohort (n = 38) was studied in an open-label study. Re...
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| Veröffentlicht in: | Pharmacogenomics 2016-11, Vol.17 (16), p.1765-1773 |
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| creator | Pau, Cindy T Cheang, Kai I Modi, Bhavi P Kasippillai, Thushiga Keefe, Candace C Shulleeta, Maria Evans, William S Pal, Lubna Strauss, Jerome F Nestler, John E Welt, Corrine K |
| description | Variants in genes encoding metformin transport proteins and the
gene are associated with metformin response. We hypothesized that these gene variants contribute to variable metformin treatment response in polycystic ovary syndrome.
The discovery cohort (n = 38) was studied in an open-label study. Results were replicated in two additional cohorts (n = 26 and n = 131). Response was assessed after 3-6 months of treatment with metformin extended-release 1500-2000 mg/day.
The rs683369 variant was associated with less weight loss in the discovery cohort (p = 0.003), but these results were not replicated (p = 0.8). There were no differences in glucose parameters, testosterone levels or ovulatory frequency as a function of genotype.
Variants in organic ion transporters do not explain the variable metformin response in polycystic ovary syndrome. |
| doi_str_mv | 10.2217/pgs-2016-0079 |
| format | Article |
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gene are associated with metformin response. We hypothesized that these gene variants contribute to variable metformin treatment response in polycystic ovary syndrome.
The discovery cohort (n = 38) was studied in an open-label study. Results were replicated in two additional cohorts (n = 26 and n = 131). Response was assessed after 3-6 months of treatment with metformin extended-release 1500-2000 mg/day.
The rs683369 variant was associated with less weight loss in the discovery cohort (p = 0.003), but these results were not replicated (p = 0.8). There were no differences in glucose parameters, testosterone levels or ovulatory frequency as a function of genotype.
Variants in organic ion transporters do not explain the variable metformin response in polycystic ovary syndrome.</description><identifier>ISSN: 1462-2416</identifier><identifier>EISSN: 1744-8042</identifier><identifier>DOI: 10.2217/pgs-2016-0079</identifier><identifier>PMID: 27790932</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antidiabetics ; Ataxia telangiectasia mutated protein ; Genomics ; Genotypes ; Glucose ; insulin ; Insulin resistance ; Kinases ; MATE ; Metformin ; OCT ; Polycystic ovary syndrome ; Testosterone</subject><ispartof>Pharmacogenomics, 2016-11, Vol.17 (16), p.1765-1773</ispartof><rights>Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Nov 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-23b88d5819273c0140df05fbf9f0eeb7da501f81a203b9a707375a2ea7aff0a63</citedby><cites>FETCH-LOGICAL-c371t-23b88d5819273c0140df05fbf9f0eeb7da501f81a203b9a707375a2ea7aff0a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27790932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pau, Cindy T</creatorcontrib><creatorcontrib>Cheang, Kai I</creatorcontrib><creatorcontrib>Modi, Bhavi P</creatorcontrib><creatorcontrib>Kasippillai, Thushiga</creatorcontrib><creatorcontrib>Keefe, Candace C</creatorcontrib><creatorcontrib>Shulleeta, Maria</creatorcontrib><creatorcontrib>Evans, William S</creatorcontrib><creatorcontrib>Pal, Lubna</creatorcontrib><creatorcontrib>Strauss, Jerome F</creatorcontrib><creatorcontrib>Nestler, John E</creatorcontrib><creatorcontrib>Welt, Corrine K</creatorcontrib><title>The role of variants regulating metformin transport and action in women with polycystic ovary syndrome</title><title>Pharmacogenomics</title><addtitle>Pharmacogenomics</addtitle><description>Variants in genes encoding metformin transport proteins and the
gene are associated with metformin response. We hypothesized that these gene variants contribute to variable metformin treatment response in polycystic ovary syndrome.
The discovery cohort (n = 38) was studied in an open-label study. Results were replicated in two additional cohorts (n = 26 and n = 131). Response was assessed after 3-6 months of treatment with metformin extended-release 1500-2000 mg/day.
The rs683369 variant was associated with less weight loss in the discovery cohort (p = 0.003), but these results were not replicated (p = 0.8). There were no differences in glucose parameters, testosterone levels or ovulatory frequency as a function of genotype.
Variants in organic ion transporters do not explain the variable metformin response in polycystic ovary syndrome.</description><subject>Antidiabetics</subject><subject>Ataxia telangiectasia mutated protein</subject><subject>Genomics</subject><subject>Genotypes</subject><subject>Glucose</subject><subject>insulin</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>MATE</subject><subject>Metformin</subject><subject>OCT</subject><subject>Polycystic ovary syndrome</subject><subject>Testosterone</subject><issn>1462-2416</issn><issn>1744-8042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kT1v3SAUhlGVqknTjl0jpC5d3B7ANmaMovRDitQlnRHGhxsiGxzAie6_L1c36VApC58Pj87hJeQTg6-cM_lt3eWGA-sbAKnekDMm27YZoOUndd32vOEt60_J-5zvATjrW3hHTrmUCpTgZ8Td3iFNcUYaHX00yZtQMk2422ZTfNjRBYuLafGBlmRCXmMq1ISJGlt8DLSeP8UF6-jLHV3jvLf7XLylscr2NO_DlOr9B_LWmTnjx-f5nPz5fn179bO5-f3j19XlTWOFZKXhYhyGqRuY4lJYYC1MDjo3OuUAcZST6YC5gRkOYlRGghSyMxyNNM6B6cU5-XL0rik-bJiLXny2OM8mYNyyZoPo-oGrVlT083_ofdxSqNVpLnivqrk_CJsjZVPMOaHTa_JLbU0z0IcAdA1AHwLQhwAqf_Fs3cYFp3_0y49XQB0Bt5UtYbYeg0V93NUX3vqAr8j_AgMjlgc</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Pau, Cindy T</creator><creator>Cheang, Kai I</creator><creator>Modi, Bhavi P</creator><creator>Kasippillai, Thushiga</creator><creator>Keefe, Candace C</creator><creator>Shulleeta, Maria</creator><creator>Evans, William S</creator><creator>Pal, Lubna</creator><creator>Strauss, Jerome F</creator><creator>Nestler, John E</creator><creator>Welt, Corrine K</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>The role of variants regulating metformin transport and action in women with polycystic ovary syndrome</title><author>Pau, Cindy T ; Cheang, Kai I ; Modi, Bhavi P ; Kasippillai, Thushiga ; Keefe, Candace C ; Shulleeta, Maria ; Evans, William S ; Pal, Lubna ; Strauss, Jerome F ; Nestler, John E ; Welt, Corrine K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-23b88d5819273c0140df05fbf9f0eeb7da501f81a203b9a707375a2ea7aff0a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antidiabetics</topic><topic>Ataxia telangiectasia mutated protein</topic><topic>Genomics</topic><topic>Genotypes</topic><topic>Glucose</topic><topic>insulin</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>MATE</topic><topic>Metformin</topic><topic>OCT</topic><topic>Polycystic ovary syndrome</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pau, Cindy T</creatorcontrib><creatorcontrib>Cheang, Kai I</creatorcontrib><creatorcontrib>Modi, Bhavi P</creatorcontrib><creatorcontrib>Kasippillai, Thushiga</creatorcontrib><creatorcontrib>Keefe, Candace C</creatorcontrib><creatorcontrib>Shulleeta, Maria</creatorcontrib><creatorcontrib>Evans, William S</creatorcontrib><creatorcontrib>Pal, Lubna</creatorcontrib><creatorcontrib>Strauss, Jerome F</creatorcontrib><creatorcontrib>Nestler, John E</creatorcontrib><creatorcontrib>Welt, Corrine K</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pau, Cindy T</au><au>Cheang, Kai I</au><au>Modi, Bhavi P</au><au>Kasippillai, Thushiga</au><au>Keefe, Candace C</au><au>Shulleeta, Maria</au><au>Evans, William S</au><au>Pal, Lubna</au><au>Strauss, Jerome F</au><au>Nestler, John E</au><au>Welt, Corrine K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of variants regulating metformin transport and action in women with polycystic ovary syndrome</atitle><jtitle>Pharmacogenomics</jtitle><addtitle>Pharmacogenomics</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>17</volume><issue>16</issue><spage>1765</spage><epage>1773</epage><pages>1765-1773</pages><issn>1462-2416</issn><eissn>1744-8042</eissn><abstract>Variants in genes encoding metformin transport proteins and the
gene are associated with metformin response. We hypothesized that these gene variants contribute to variable metformin treatment response in polycystic ovary syndrome.
The discovery cohort (n = 38) was studied in an open-label study. Results were replicated in two additional cohorts (n = 26 and n = 131). Response was assessed after 3-6 months of treatment with metformin extended-release 1500-2000 mg/day.
The rs683369 variant was associated with less weight loss in the discovery cohort (p = 0.003), but these results were not replicated (p = 0.8). There were no differences in glucose parameters, testosterone levels or ovulatory frequency as a function of genotype.
Variants in organic ion transporters do not explain the variable metformin response in polycystic ovary syndrome.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>27790932</pmid><doi>10.2217/pgs-2016-0079</doi><tpages>9</tpages></addata></record> |
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| subjects | Antidiabetics Ataxia telangiectasia mutated protein Genomics Genotypes Glucose insulin Insulin resistance Kinases MATE Metformin OCT Polycystic ovary syndrome Testosterone |
| title | The role of variants regulating metformin transport and action in women with polycystic ovary syndrome |
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