Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway

Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer. In the present study, we examined the effects of lapatinib on growth of oral and prostate cancer cells. Oral squamou...

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Veröffentlicht in:	Oncology reports 2016-11, Vol.36 (5), p.3058-3064
Hauptverfasser:	Ohnishi, Yuichi, Yasui, Hiroki, Kakudo, Kenji, Nozaki, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Breast cancer Cadherins - biosynthesis cancer stem cells Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell growth Cell Line, Tumor cyclin D1 Cyclin D1 - biosynthesis Cyclin D1 - genetics cyclin D2 Cyclin D2 - biosynthesis Cyclin D2 - genetics Development and progression Drug Resistance, Neoplasm - drug effects Drug therapy EGFR ErbB Female Gene Expression Regulation, Neoplastic Humans Inhibitor drugs Kinases lapatinib Ligands Male Mouth cancer Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Mouth Neoplasms - pathology Oral cancer Phosphorylation Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proteins Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-akt - genetics Quinazolines - administration & dosage Receptor, Epidermal Growth Factor - biosynthesis Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Receptor, ErbB-3 - biosynthesis Receptor, ErbB-3 - genetics Signal transduction sphere Squamous cell carcinoma Studies Targeted cancer therapy Tumors
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