The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats

Highlights • Central microinfusion of a selective CB2 agonist (AM1241) increases PTZ-induced seizures in rats. • Blockade of CB2 cannabinoid receptors prevents the proconvulsant effects of AM1241. • Proconvulsant effects of AM1241 are mediated by CB2 receptors.

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Bibliographische Detailangaben
Veröffentlicht in:	Epilepsy research 2016-11, Vol.127, p.160-167
Hauptverfasser:	de Carvalho, Cristiane R, Hoeller, Alexandre A, Franco, Pedro L.C, Martini, Athos P.S, Soares, Flávia M.S, Lin, Katia, Prediger, Rui D, Whalley, Benjamin J, Walz, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cannabinoid Receptor Agonists - pharmacology Cannabinoids - pharmacology Catheters, Indwelling CB2 cannabinoid receptors Convulsants - pharmacology Dose-Response Relationship, Drug Drug Synergism Epilepsy Injections, Intraperitoneal Male Microinjections Neurology Pentylenetetrazole Pentylenetetrazole - pharmacology Proconvulsant Rats, Wistar Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Seizures Seizures - chemically induced Seizures - metabolism Seizures - mortality Severity of Illness Index
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Beschreibung
Zusammenfassung:	Highlights • Central microinfusion of a selective CB2 agonist (AM1241) increases PTZ-induced seizures in rats. • Blockade of CB2 cannabinoid receptors prevents the proconvulsant effects of AM1241. • Proconvulsant effects of AM1241 are mediated by CB2 receptors.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2016.08.011