Influence of antiepileptic drugs on serum lipid levels in adult epilepsy patients

Highlights • Use of enzyme-inducing antiepileptic drug caused a marked increase of lipid levels. • Carbamazepine had a strong influence on lipid levels. • Valproic acid decreased HDL cholesterol and increased non-HDL cholesterol. • Increasing age and BMI, and male gender enhanced the risk of dyslipi...

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Veröffentlicht in:	Epilepsy research 2016-11, Vol.127, p.101-106
Hauptverfasser:	Yamamoto, Yoshiaki, Terada, Kiyohito, Takahashi, Yukitoshi, Imai, Katsumi, Kagawa, Yoshiyuki, Inoue, Yushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Biomarkers - blood Body Mass Index Carbamazepine CYP51A1 Dyslipidemia Dyslipidemias - blood Dyslipidemias - epidemiology Enzyme induction Epilepsy - blood Epilepsy - drug therapy Epilepsy - epidemiology Female Humans Lipids - blood Logistic Models Male Middle Aged Neurology Pharmacoepidemiology Retrospective Studies Risk Factors Sex Factors Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Use of enzyme-inducing antiepileptic drug caused a marked increase of lipid levels. • Carbamazepine had a strong influence on lipid levels. • Valproic acid decreased HDL cholesterol and increased non-HDL cholesterol. • Increasing age and BMI, and male gender enhanced the risk of dyslipidemia
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2016.08.027