Corrected Fructosamine improves both correlation with HbA1C and diagnostic performance
There is increasing interest in using fructosamine measurements in screening for or managing diabetes, yet uncertainty remains as to whether these measurements should be corrected for variation in serum protein concentrations. We considered all sets of simultaneous measurements of fructosamine, albu...
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| Veröffentlicht in: | Clinical biochemistry 2017-02, Vol.50 (3), p.110-115 |
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| creator | Rodríguez-Segade, S. Rodríguez, J. Camiña, F. |
| description | There is increasing interest in using fructosamine measurements in screening for or managing diabetes, yet uncertainty remains as to whether these measurements should be corrected for variation in serum protein concentrations.
We considered all sets of simultaneous measurements of fructosamine, albumin, total serum protein (TP), fasting plasma glucose (FPG) and HbA1C recorded in our laboratory over 10years. The relationships between fructosamine and other variables were studied by multivariate linear regression and other analyses, and receiver operating curves (ROCs) were analysed to compare the diabetes screening performance of uncorrected fructosamine to those of albumin-corrected fructosamine (FAAlb) and TP-corrected fructosamine (FATP).
40,938 sets of measurements were collected from 20,114 patients. Though correlation between fructosamine and serum proteins was strongest among patients with HbA1C |
| doi_str_mv | 10.1016/j.clinbiochem.2016.10.014 |
| format | Article |
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We considered all sets of simultaneous measurements of fructosamine, albumin, total serum protein (TP), fasting plasma glucose (FPG) and HbA1C recorded in our laboratory over 10years. The relationships between fructosamine and other variables were studied by multivariate linear regression and other analyses, and receiver operating curves (ROCs) were analysed to compare the diabetes screening performance of uncorrected fructosamine to those of albumin-corrected fructosamine (FAAlb) and TP-corrected fructosamine (FATP).
40,938 sets of measurements were collected from 20,114 patients. Though correlation between fructosamine and serum proteins was strongest among patients with HbA1C <6.5% (48mmol/mol), it was also significant in the whole sample (r=0.193 for albumin, r=0.213 for TP). With diabetes defined by HbA1C ≥6.5% (48mmol/mol), the areas under the ROCs of FAAlb (0.905) and FATP (0.895) were both significantly greater (P<0.001) than that of uncorrected fructosamine (0.878). Correction of fructosamine for albumin or TP slightly improved its correlation with HbA1C. There was no correlation of protein (albumin or TP) with log(fructosamine/protein).
Fructosamine concentration correlates significantly with albumin and total protein concentrations throughout their ranges. Correction of fructosamine improves its correlation with HbA1C and its performance in detecting diabetes.
[Display omitted]
•Uncorrected Fructosamine is often used in clinical practice•This study includes 40,938 sets of simultaneous measurements of glycemic control parameters from 20,114 patients.•Fructosamine was determined by a highly specific enzymatic method.•Fructosamine concentration is significantly influenced by serum protein concentration.•Albumin-corrected fructosamine improves correlation with HbA1C, FPG and diagnostic performance.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2016.10.014</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Albumin ; Fructosamine ; HbA1C ; Total serum protein ; Type 1 diabetes ; Type 2 diabetes</subject><ispartof>Clinical biochemistry, 2017-02, Vol.50 (3), p.110-115</ispartof><rights>2016 The Canadian Society of Clinical Chemists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c269t-b49680faaa682e70441f593e6b78b68cad821b687c2508e6b32d1a5f2ba9f8153</citedby><cites>FETCH-LOGICAL-c269t-b49680faaa682e70441f593e6b78b68cad821b687c2508e6b32d1a5f2ba9f8153</cites><orcidid>0000-0002-5470-3700</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912016304507$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Rodríguez-Segade, S.</creatorcontrib><creatorcontrib>Rodríguez, J.</creatorcontrib><creatorcontrib>Camiña, F.</creatorcontrib><title>Corrected Fructosamine improves both correlation with HbA1C and diagnostic performance</title><title>Clinical biochemistry</title><description>There is increasing interest in using fructosamine measurements in screening for or managing diabetes, yet uncertainty remains as to whether these measurements should be corrected for variation in serum protein concentrations.
We considered all sets of simultaneous measurements of fructosamine, albumin, total serum protein (TP), fasting plasma glucose (FPG) and HbA1C recorded in our laboratory over 10years. The relationships between fructosamine and other variables were studied by multivariate linear regression and other analyses, and receiver operating curves (ROCs) were analysed to compare the diabetes screening performance of uncorrected fructosamine to those of albumin-corrected fructosamine (FAAlb) and TP-corrected fructosamine (FATP).
40,938 sets of measurements were collected from 20,114 patients. Though correlation between fructosamine and serum proteins was strongest among patients with HbA1C <6.5% (48mmol/mol), it was also significant in the whole sample (r=0.193 for albumin, r=0.213 for TP). With diabetes defined by HbA1C ≥6.5% (48mmol/mol), the areas under the ROCs of FAAlb (0.905) and FATP (0.895) were both significantly greater (P<0.001) than that of uncorrected fructosamine (0.878). Correction of fructosamine for albumin or TP slightly improved its correlation with HbA1C. There was no correlation of protein (albumin or TP) with log(fructosamine/protein).
Fructosamine concentration correlates significantly with albumin and total protein concentrations throughout their ranges. Correction of fructosamine improves its correlation with HbA1C and its performance in detecting diabetes.
[Display omitted]
•Uncorrected Fructosamine is often used in clinical practice•This study includes 40,938 sets of simultaneous measurements of glycemic control parameters from 20,114 patients.•Fructosamine was determined by a highly specific enzymatic method.•Fructosamine concentration is significantly influenced by serum protein concentration.•Albumin-corrected fructosamine improves correlation with HbA1C, FPG and diagnostic performance.</description><subject>Albumin</subject><subject>Fructosamine</subject><subject>HbA1C</subject><subject>Total serum protein</subject><subject>Type 1 diabetes</subject><subject>Type 2 diabetes</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkE1PwzAMhiMEEuPjP4Qbl5Z8tGlynCrGkCZxAa5RmrosU9uMpBvi35NqHDhysv36tWU_CN1RklNCxcMut70bG-ftFoacJSnpOaHFGVpQWfGMKc7P0YIQojJFGblEVzHuUskKKRbovfYhgJ2gxatwsJOPZnAjYDfsgz9CxI2fttjOpt5Mzo_4yyVh3Sxpjc3Y4taZj9HHyVm8h9D5MJjRwg266Ewf4fY3XqO31eNrvc42L0_P9XKTWSbUlDWFEpJ0xhghGVSkKGhXKg6iqWQjpDWtZDQllWUlkUnmrKWm7FhjVCdpya_R_WlvuvbzAHHSg4sW-t6M4A9RU8lLUXGqqmRVJ6sNPsYAnd4HN5jwrSnRM0u9039Y6pnl3Eos02x9moX0y9FB0NE6SH-2boanW-_-seUH6H6ECw</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Rodríguez-Segade, S.</creator><creator>Rodríguez, J.</creator><creator>Camiña, F.</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5470-3700</orcidid></search><sort><creationdate>201702</creationdate><title>Corrected Fructosamine improves both correlation with HbA1C and diagnostic performance</title><author>Rodríguez-Segade, S. ; Rodríguez, J. ; Camiña, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c269t-b49680faaa682e70441f593e6b78b68cad821b687c2508e6b32d1a5f2ba9f8153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Albumin</topic><topic>Fructosamine</topic><topic>HbA1C</topic><topic>Total serum protein</topic><topic>Type 1 diabetes</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Segade, S.</creatorcontrib><creatorcontrib>Rodríguez, J.</creatorcontrib><creatorcontrib>Camiña, F.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Segade, S.</au><au>Rodríguez, J.</au><au>Camiña, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corrected Fructosamine improves both correlation with HbA1C and diagnostic performance</atitle><jtitle>Clinical biochemistry</jtitle><date>2017-02</date><risdate>2017</risdate><volume>50</volume><issue>3</issue><spage>110</spage><epage>115</epage><pages>110-115</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>There is increasing interest in using fructosamine measurements in screening for or managing diabetes, yet uncertainty remains as to whether these measurements should be corrected for variation in serum protein concentrations.
We considered all sets of simultaneous measurements of fructosamine, albumin, total serum protein (TP), fasting plasma glucose (FPG) and HbA1C recorded in our laboratory over 10years. The relationships between fructosamine and other variables were studied by multivariate linear regression and other analyses, and receiver operating curves (ROCs) were analysed to compare the diabetes screening performance of uncorrected fructosamine to those of albumin-corrected fructosamine (FAAlb) and TP-corrected fructosamine (FATP).
40,938 sets of measurements were collected from 20,114 patients. Though correlation between fructosamine and serum proteins was strongest among patients with HbA1C <6.5% (48mmol/mol), it was also significant in the whole sample (r=0.193 for albumin, r=0.213 for TP). With diabetes defined by HbA1C ≥6.5% (48mmol/mol), the areas under the ROCs of FAAlb (0.905) and FATP (0.895) were both significantly greater (P<0.001) than that of uncorrected fructosamine (0.878). Correction of fructosamine for albumin or TP slightly improved its correlation with HbA1C. There was no correlation of protein (albumin or TP) with log(fructosamine/protein).
Fructosamine concentration correlates significantly with albumin and total protein concentrations throughout their ranges. Correction of fructosamine improves its correlation with HbA1C and its performance in detecting diabetes.
[Display omitted]
•Uncorrected Fructosamine is often used in clinical practice•This study includes 40,938 sets of simultaneous measurements of glycemic control parameters from 20,114 patients.•Fructosamine was determined by a highly specific enzymatic method.•Fructosamine concentration is significantly influenced by serum protein concentration.•Albumin-corrected fructosamine improves correlation with HbA1C, FPG and diagnostic performance.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.clinbiochem.2016.10.014</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5470-3700</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical biochemistry, 2017-02, Vol.50 (3), p.110-115 |
| issn | 0009-9120 1873-2933 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Albumin Fructosamine HbA1C Total serum protein Type 1 diabetes Type 2 diabetes |
| title | Corrected Fructosamine improves both correlation with HbA1C and diagnostic performance |
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