Rapid permissive action of dexamethasone on the regulation of blood pressure in a rat model of septic shock

Abstract Glucocorticoids (GCs) play a vital role in the regulation of blood pressure by their permissive effects in potentiating vasoactive responses to catecholamines through glucocorticoid receptors. GCs achieve this function by controlling vascular smooth muscle tone. Clinically, low to moderate...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-12, Vol.84, p.1119-1125
Hauptverfasser:	Shi, Wen-Lei, Post Doc, Zhang, Ting, M.M, Zhou, Jiang-Rui, M.M, Huang, Yong-Hua, PhD, Jiang, Chun-Lei, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Adrenalectomy Animals Blood pressure Blood Pressure - drug effects Cecum - microbiology Cecum - surgery Cells, Cultured Dexamethasone - pharmacology Disease Models, Animal Glucocorticoids Glucocorticoids - pharmacology Internal Medicine Ligation Male Medical Education Mesenteric Arteries - drug effects Mesenteric Arteries - physiopathology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - drug effects Norepinephrine Norepinephrine - pharmacology Punctures Rats, Sprague-Dawley Shock, Septic - drug therapy Shock, Septic - microbiology Shock, Septic - physiopathology Time Factors Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology
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