Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma

As a crucial antioxidant enzyme, glutathione peroxidase 3 (GPX3) has been found to be frequently repressed in many cancers due to promoter hypermethylation and is known as a possible tumor suppressor gene. In the present study, we investigated whether promoter hypermethylation of GPX3 and its repres...

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Veröffentlicht in:	Oncology reports 2016-11, Vol.36 (5), p.2737-2744
Hauptverfasser:	Chen, Haiyue, Zheng, Zhenlong, Kim, Ki-Yeol, Jin, Xuemei, Roh, Mi Ryung, Jin, Zhehu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigens Antioxidants Azacitidine - administration & dosage Azacitidine - analogs & derivatives Care and treatment Child Development and progression DNA Methylation - drug effects DNA Methylation - genetics Epigenetics Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic - drug effects Genes Genetic aspects Glutathione Peroxidase - biosynthesis Glutathione Peroxidase - genetics GPX3 Health aspects Humans Male Medical prognosis Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - pathology Metastasis Middle Aged Motility Pathogenesis Peroxidase promoter hypermethylation Promoter Regions, Genetic - genetics Prostate cancer RNA, Messenger - biosynthesis Rodents Selenium Skin cancer Tumor suppressor genes
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