Evaluation of the Interplay between Uptake Transport and CYP3A4 Induction in Micropatterned Cocultured Hepatocytes

Previously we assessed the inductive response of prototypical inducers in hepatocyte monocultures and the long-term coculture model HepatoPac using cryopreserved hepatocytes from the same donors. We noted that the rifampicin EC generated using the HepatoPac model corresponded better to the EC based...

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Veröffentlicht in:	Drug metabolism and disposition 2016-12, Vol.44 (12), p.1910-1919
Hauptverfasser:	Moore, Amanda, Chothe, Paresh P, Tsao, Hong, Hariparsad, Niresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport - drug effects Biological Transport - physiology Cells, Cultured Coculture Techniques - methods Cryopreservation - methods Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inducers - pharmacology Drug Interactions - physiology Hepatocytes - drug effects Hepatocytes - metabolism Humans Liver - drug effects Liver - metabolism Rifampin - pharmacology RNA, Messenger - metabolism
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