Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

A novel type of bio‐nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one‐step method. Such bio‐nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2O2 in a tumor microenvironment, and thus synergistic...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-09, Vol.28 (33), p.7143-7148
Hauptverfasser:	Song, Guosheng, Chen, Yuyan, Liang, Chao, Yi, Xuan, Liu, Jingjing, Sun, Xiaoqi, Shen, Sida, Yang, Kai, Liu, Zhuang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bio-nanoreactors Cancer Catalase Catalase - administration & dosage Catalase - metabolism Effectiveness enzyme delivery hypoxia Mice Nanoshells - administration & dosage Nanoshells - chemistry Nanostructure Neoplasms - metabolism Neoplasms - radiotherapy Oxygen - metabolism Oxygenation Radiotherapy Supplying tantalum oxide Tumor Microenvironment Tumors
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Beschreibung
Zusammenfassung:	A novel type of bio‐nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one‐step method. Such bio‐nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia‐induced radiotherapy resistance.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201602111