Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development

[Display omitted] The use of small molecules to regulate cellular levels of specific proteins is poised to become a powerful technique in the coming years. Critical to the success of any project utilizing such an approach will be the ability to synthesize libraries of candidate small molecules for t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-11, Vol.26 (21), p.5260-5262
Hauptverfasser:	Lohbeck, Jasmin, Miller, Aubry K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cereblon E3 ligase Humans Ligands Peptide Hydrolases - chemistry Phthalimides - chemical synthesis Phthalimides - chemistry PROTACs Proteolysis Thalidomide
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!