Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury
BACKGROUND:Patients experiencing acute lung injury (ALI) often need mechanical ventilation for which sedation may be required. In such patients, usually the first choice an intravenously administered drug. However, growing evidence suggests that volatile anesthetics such as sevoflurane are a valuabl...
Gespeichert in:
| Veröffentlicht in: | Anesthesia and analgesia 2017-01, Vol.124 (1), p.194-203 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 203 |
|---|---|
| container_issue | 1 |
| container_start_page | 194 |
| container_title | Anesthesia and analgesia |
| container_volume | 124 |
| creator | Kellner, Patrick Müller, Mattia Piegeler, Tobias Eugster, Philipp Booy, Christa Schläpfer, Martin Beck-Schimmer, Beatrice |
| description | BACKGROUND:Patients experiencing acute lung injury (ALI) often need mechanical ventilation for which sedation may be required. In such patients, usually the first choice an intravenously administered drug. However, growing evidence suggests that volatile anesthetics such as sevoflurane are a valuable alternative. In this study, we evaluate pulmonary and systemic effects of long-term (24-hour) sedation with sevoflurane compared with propofol in an in vivo animal model of ALI.
METHODS:Adult male Wistar rats were subjected to ALI by intratracheal lipopolysaccharide (LPS) application, mechanically ventilated and sedated for varying intervals up to 24 hours with either sevoflurane or propofol. Vital parameters were monitored, and arterial blood gases were analyzed. Inflammation was assessed by the analysis of bronchoalveolar lavage fluid (BALF), cytokines (monocyte chemoattractant protein-1 [MCP-1], cytokine-induced neutrophil chemoattractant protein-1 [CINC-1], interleukin [IL-6], IL-12/12a, transforming growth factor-β, and IL-10) in blood and lung tissue and inflammatory cells. The alveolocapillary barrier was indirectly assessed by wet-to-dry ratio, albumin, and total protein content in BALF. Results are presented as mean ± standard deviation.
RESULTS:After 9 hours of ventilation and sedation, oxygenation index was higher in the LPS/sevoflurane (LPS-S) than in the LPS/propofol group (LPS-P) and reached 400 ± 67 versus 262 ± 57 mm Hg after 24 hours (P < .001). Cell count in BALF in sevoflurane-treated animals was lower after 18 hours (P = .001) and 24 hours (P < .001) than in propofol controls. Peak values of CINC-1 and IL-6 in BALF were lower in LPS-S versus LPS-P animals (CINC-12.7 ± 0.7 vs 4.0 ± 0.9 ng/mL; IL-69.2 ± 2.3 vs 18.9 ± 7.1 pg/mL, both P < .001), whereas IL-10 and MCP-1 did not differ. Also messenger RNAs of CINC-1, IL-6, IL-12a, and IL-10 were significantly higher in LPS-P compared with LPS-S. MCP-1 and transforming growth factor-β showed no differences. Wet-to-dry ratio was lower in LPS-S (5.4 ± 0.2 vs 5.7 ± 0.2, P = .016). Total protein in BALF did not differ between P-LPS and S-LPS groups.
CONCLUSIONS:Long-term sedation with sevoflurane compared with propofol improves oxygenation and attenuates the inflammatory response in LPS-induced ALI. Our findings suggest that sevoflurane may improve lung function when used for sedation in patients with ALI. |
| doi_str_mv | 10.1213/ANE.0000000000001530 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835646585</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835646585</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4020-dc4cdf059bab57263f06dbbfdf0522b952211a14a1dbf013190b409fc833c38e3</originalsourceid><addsrcrecordid>eNp9kM1OwzAQhC0EglJ4A4R85BLwT5LaxwoVqFSoBOXCJbKTdZvixMVOgL49qVoQ4sAedqXRN7vaQeiMkkvKKL8aPowuya-iCSd7qEcTlkaDRIp91OtUHjEp5RE6DmG5gYhID9ERGwwEk7HooZcneHfGtl7VgIfa2TIsIODp53oOtWpKV-NxtVKlr6BucFljhSeunkcz8BV-VA2-dwVY7Awe5m0DeNLWczyul61fn6ADo2yA093so-eb0ez6LppMb8fXw0mUx4SRqMjjvDAkkVrpZMBSbkhaaG02GmNado1SRWNFC20I5VQSHRNpcsF5zgXwPrrY7l1599ZCaLKqDDlY273k2pBRwZM0ThORdGi8RXPvQvBgspUvK-XXGSXZJtWsSzX7m2pnO99daHUFxY_pO8YOEFvgw9kGfHi17Qf4bAHKNov_d38BDRSCxg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835646585</pqid></control><display><type>article</type><title>Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Kellner, Patrick ; Müller, Mattia ; Piegeler, Tobias ; Eugster, Philipp ; Booy, Christa ; Schläpfer, Martin ; Beck-Schimmer, Beatrice</creator><creatorcontrib>Kellner, Patrick ; Müller, Mattia ; Piegeler, Tobias ; Eugster, Philipp ; Booy, Christa ; Schläpfer, Martin ; Beck-Schimmer, Beatrice</creatorcontrib><description>BACKGROUND:Patients experiencing acute lung injury (ALI) often need mechanical ventilation for which sedation may be required. In such patients, usually the first choice an intravenously administered drug. However, growing evidence suggests that volatile anesthetics such as sevoflurane are a valuable alternative. In this study, we evaluate pulmonary and systemic effects of long-term (24-hour) sedation with sevoflurane compared with propofol in an in vivo animal model of ALI.
METHODS:Adult male Wistar rats were subjected to ALI by intratracheal lipopolysaccharide (LPS) application, mechanically ventilated and sedated for varying intervals up to 24 hours with either sevoflurane or propofol. Vital parameters were monitored, and arterial blood gases were analyzed. Inflammation was assessed by the analysis of bronchoalveolar lavage fluid (BALF), cytokines (monocyte chemoattractant protein-1 [MCP-1], cytokine-induced neutrophil chemoattractant protein-1 [CINC-1], interleukin [IL-6], IL-12/12a, transforming growth factor-β, and IL-10) in blood and lung tissue and inflammatory cells. The alveolocapillary barrier was indirectly assessed by wet-to-dry ratio, albumin, and total protein content in BALF. Results are presented as mean ± standard deviation.
RESULTS:After 9 hours of ventilation and sedation, oxygenation index was higher in the LPS/sevoflurane (LPS-S) than in the LPS/propofol group (LPS-P) and reached 400 ± 67 versus 262 ± 57 mm Hg after 24 hours (P < .001). Cell count in BALF in sevoflurane-treated animals was lower after 18 hours (P = .001) and 24 hours (P < .001) than in propofol controls. Peak values of CINC-1 and IL-6 in BALF were lower in LPS-S versus LPS-P animals (CINC-12.7 ± 0.7 vs 4.0 ± 0.9 ng/mL; IL-69.2 ± 2.3 vs 18.9 ± 7.1 pg/mL, both P < .001), whereas IL-10 and MCP-1 did not differ. Also messenger RNAs of CINC-1, IL-6, IL-12a, and IL-10 were significantly higher in LPS-P compared with LPS-S. MCP-1 and transforming growth factor-β showed no differences. Wet-to-dry ratio was lower in LPS-S (5.4 ± 0.2 vs 5.7 ± 0.2, P = .016). Total protein in BALF did not differ between P-LPS and S-LPS groups.
CONCLUSIONS:Long-term sedation with sevoflurane compared with propofol improves oxygenation and attenuates the inflammatory response in LPS-induced ALI. Our findings suggest that sevoflurane may improve lung function when used for sedation in patients with ALI.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/ANE.0000000000001530</identifier><identifier>PMID: 27782948</identifier><language>eng</language><publisher>United States: International Anesthesia Research Society</publisher><subject><![CDATA[Acute Lung Injury - blood ; Acute Lung Injury - chemically induced ; Acute Lung Injury - physiopathology ; Acute Lung Injury - therapy ; Anesthetics, Inhalation - administration & dosage ; Anesthetics, Intravenous - administration & dosage ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Biomarkers - blood ; Blood-Air Barrier - drug effects ; Blood-Air Barrier - metabolism ; Bronchoalveolar Lavage Fluid - chemistry ; Capillary Permeability - drug effects ; Cytokines - blood ; Cytokines - genetics ; Disease Models, Animal ; Hemodynamics - drug effects ; Inflammation Mediators - blood ; Kidney - drug effects ; Kidney - physiopathology ; Lipopolysaccharides ; Lung - drug effects ; Lung - metabolism ; Male ; Methyl Ethers - administration & dosage ; Oxygen - blood ; Pneumonia - blood ; Pneumonia - chemically induced ; Pneumonia - physiopathology ; Pneumonia - prevention & control ; Propofol - administration & dosage ; Rats, Wistar ; Respiration, Artificial ; Time Factors]]></subject><ispartof>Anesthesia and analgesia, 2017-01, Vol.124 (1), p.194-203</ispartof><rights>2016 International Anesthesia Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4020-dc4cdf059bab57263f06dbbfdf0522b952211a14a1dbf013190b409fc833c38e3</citedby><cites>FETCH-LOGICAL-c4020-dc4cdf059bab57263f06dbbfdf0522b952211a14a1dbf013190b409fc833c38e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27782948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kellner, Patrick</creatorcontrib><creatorcontrib>Müller, Mattia</creatorcontrib><creatorcontrib>Piegeler, Tobias</creatorcontrib><creatorcontrib>Eugster, Philipp</creatorcontrib><creatorcontrib>Booy, Christa</creatorcontrib><creatorcontrib>Schläpfer, Martin</creatorcontrib><creatorcontrib>Beck-Schimmer, Beatrice</creatorcontrib><title>Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>BACKGROUND:Patients experiencing acute lung injury (ALI) often need mechanical ventilation for which sedation may be required. In such patients, usually the first choice an intravenously administered drug. However, growing evidence suggests that volatile anesthetics such as sevoflurane are a valuable alternative. In this study, we evaluate pulmonary and systemic effects of long-term (24-hour) sedation with sevoflurane compared with propofol in an in vivo animal model of ALI.
METHODS:Adult male Wistar rats were subjected to ALI by intratracheal lipopolysaccharide (LPS) application, mechanically ventilated and sedated for varying intervals up to 24 hours with either sevoflurane or propofol. Vital parameters were monitored, and arterial blood gases were analyzed. Inflammation was assessed by the analysis of bronchoalveolar lavage fluid (BALF), cytokines (monocyte chemoattractant protein-1 [MCP-1], cytokine-induced neutrophil chemoattractant protein-1 [CINC-1], interleukin [IL-6], IL-12/12a, transforming growth factor-β, and IL-10) in blood and lung tissue and inflammatory cells. The alveolocapillary barrier was indirectly assessed by wet-to-dry ratio, albumin, and total protein content in BALF. Results are presented as mean ± standard deviation.
RESULTS:After 9 hours of ventilation and sedation, oxygenation index was higher in the LPS/sevoflurane (LPS-S) than in the LPS/propofol group (LPS-P) and reached 400 ± 67 versus 262 ± 57 mm Hg after 24 hours (P < .001). Cell count in BALF in sevoflurane-treated animals was lower after 18 hours (P = .001) and 24 hours (P < .001) than in propofol controls. Peak values of CINC-1 and IL-6 in BALF were lower in LPS-S versus LPS-P animals (CINC-12.7 ± 0.7 vs 4.0 ± 0.9 ng/mL; IL-69.2 ± 2.3 vs 18.9 ± 7.1 pg/mL, both P < .001), whereas IL-10 and MCP-1 did not differ. Also messenger RNAs of CINC-1, IL-6, IL-12a, and IL-10 were significantly higher in LPS-P compared with LPS-S. MCP-1 and transforming growth factor-β showed no differences. Wet-to-dry ratio was lower in LPS-S (5.4 ± 0.2 vs 5.7 ± 0.2, P = .016). Total protein in BALF did not differ between P-LPS and S-LPS groups.
CONCLUSIONS:Long-term sedation with sevoflurane compared with propofol improves oxygenation and attenuates the inflammatory response in LPS-induced ALI. Our findings suggest that sevoflurane may improve lung function when used for sedation in patients with ALI.</description><subject>Acute Lung Injury - blood</subject><subject>Acute Lung Injury - chemically induced</subject><subject>Acute Lung Injury - physiopathology</subject><subject>Acute Lung Injury - therapy</subject><subject>Anesthetics, Inhalation - administration & dosage</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Biomarkers - blood</subject><subject>Blood-Air Barrier - drug effects</subject><subject>Blood-Air Barrier - metabolism</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Capillary Permeability - drug effects</subject><subject>Cytokines - blood</subject><subject>Cytokines - genetics</subject><subject>Disease Models, Animal</subject><subject>Hemodynamics - drug effects</subject><subject>Inflammation Mediators - blood</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Lipopolysaccharides</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Methyl Ethers - administration & dosage</subject><subject>Oxygen - blood</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - chemically induced</subject><subject>Pneumonia - physiopathology</subject><subject>Pneumonia - prevention & control</subject><subject>Propofol - administration & dosage</subject><subject>Rats, Wistar</subject><subject>Respiration, Artificial</subject><subject>Time Factors</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EglJ4A4R85BLwT5LaxwoVqFSoBOXCJbKTdZvixMVOgL49qVoQ4sAedqXRN7vaQeiMkkvKKL8aPowuya-iCSd7qEcTlkaDRIp91OtUHjEp5RE6DmG5gYhID9ERGwwEk7HooZcneHfGtl7VgIfa2TIsIODp53oOtWpKV-NxtVKlr6BucFljhSeunkcz8BV-VA2-dwVY7Awe5m0DeNLWczyul61fn6ADo2yA093so-eb0ez6LppMb8fXw0mUx4SRqMjjvDAkkVrpZMBSbkhaaG02GmNado1SRWNFC20I5VQSHRNpcsF5zgXwPrrY7l1599ZCaLKqDDlY273k2pBRwZM0ThORdGi8RXPvQvBgspUvK-XXGSXZJtWsSzX7m2pnO99daHUFxY_pO8YOEFvgw9kGfHi17Qf4bAHKNov_d38BDRSCxg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Kellner, Patrick</creator><creator>Müller, Mattia</creator><creator>Piegeler, Tobias</creator><creator>Eugster, Philipp</creator><creator>Booy, Christa</creator><creator>Schläpfer, Martin</creator><creator>Beck-Schimmer, Beatrice</creator><general>International Anesthesia Research Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury</title><author>Kellner, Patrick ; Müller, Mattia ; Piegeler, Tobias ; Eugster, Philipp ; Booy, Christa ; Schläpfer, Martin ; Beck-Schimmer, Beatrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4020-dc4cdf059bab57263f06dbbfdf0522b952211a14a1dbf013190b409fc833c38e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Lung Injury - blood</topic><topic>Acute Lung Injury - chemically induced</topic><topic>Acute Lung Injury - physiopathology</topic><topic>Acute Lung Injury - therapy</topic><topic>Anesthetics, Inhalation - administration & dosage</topic><topic>Anesthetics, Intravenous - administration & dosage</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Biomarkers - blood</topic><topic>Blood-Air Barrier - drug effects</topic><topic>Blood-Air Barrier - metabolism</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Capillary Permeability - drug effects</topic><topic>Cytokines - blood</topic><topic>Cytokines - genetics</topic><topic>Disease Models, Animal</topic><topic>Hemodynamics - drug effects</topic><topic>Inflammation Mediators - blood</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Lipopolysaccharides</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Methyl Ethers - administration & dosage</topic><topic>Oxygen - blood</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - chemically induced</topic><topic>Pneumonia - physiopathology</topic><topic>Pneumonia - prevention & control</topic><topic>Propofol - administration & dosage</topic><topic>Rats, Wistar</topic><topic>Respiration, Artificial</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellner, Patrick</creatorcontrib><creatorcontrib>Müller, Mattia</creatorcontrib><creatorcontrib>Piegeler, Tobias</creatorcontrib><creatorcontrib>Eugster, Philipp</creatorcontrib><creatorcontrib>Booy, Christa</creatorcontrib><creatorcontrib>Schläpfer, Martin</creatorcontrib><creatorcontrib>Beck-Schimmer, Beatrice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kellner, Patrick</au><au>Müller, Mattia</au><au>Piegeler, Tobias</au><au>Eugster, Philipp</au><au>Booy, Christa</au><au>Schläpfer, Martin</au><au>Beck-Schimmer, Beatrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>124</volume><issue>1</issue><spage>194</spage><epage>203</epage><pages>194-203</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><abstract>BACKGROUND:Patients experiencing acute lung injury (ALI) often need mechanical ventilation for which sedation may be required. In such patients, usually the first choice an intravenously administered drug. However, growing evidence suggests that volatile anesthetics such as sevoflurane are a valuable alternative. In this study, we evaluate pulmonary and systemic effects of long-term (24-hour) sedation with sevoflurane compared with propofol in an in vivo animal model of ALI.
METHODS:Adult male Wistar rats were subjected to ALI by intratracheal lipopolysaccharide (LPS) application, mechanically ventilated and sedated for varying intervals up to 24 hours with either sevoflurane or propofol. Vital parameters were monitored, and arterial blood gases were analyzed. Inflammation was assessed by the analysis of bronchoalveolar lavage fluid (BALF), cytokines (monocyte chemoattractant protein-1 [MCP-1], cytokine-induced neutrophil chemoattractant protein-1 [CINC-1], interleukin [IL-6], IL-12/12a, transforming growth factor-β, and IL-10) in blood and lung tissue and inflammatory cells. The alveolocapillary barrier was indirectly assessed by wet-to-dry ratio, albumin, and total protein content in BALF. Results are presented as mean ± standard deviation.
RESULTS:After 9 hours of ventilation and sedation, oxygenation index was higher in the LPS/sevoflurane (LPS-S) than in the LPS/propofol group (LPS-P) and reached 400 ± 67 versus 262 ± 57 mm Hg after 24 hours (P < .001). Cell count in BALF in sevoflurane-treated animals was lower after 18 hours (P = .001) and 24 hours (P < .001) than in propofol controls. Peak values of CINC-1 and IL-6 in BALF were lower in LPS-S versus LPS-P animals (CINC-12.7 ± 0.7 vs 4.0 ± 0.9 ng/mL; IL-69.2 ± 2.3 vs 18.9 ± 7.1 pg/mL, both P < .001), whereas IL-10 and MCP-1 did not differ. Also messenger RNAs of CINC-1, IL-6, IL-12a, and IL-10 were significantly higher in LPS-P compared with LPS-S. MCP-1 and transforming growth factor-β showed no differences. Wet-to-dry ratio was lower in LPS-S (5.4 ± 0.2 vs 5.7 ± 0.2, P = .016). Total protein in BALF did not differ between P-LPS and S-LPS groups.
CONCLUSIONS:Long-term sedation with sevoflurane compared with propofol improves oxygenation and attenuates the inflammatory response in LPS-induced ALI. Our findings suggest that sevoflurane may improve lung function when used for sedation in patients with ALI.</abstract><cop>United States</cop><pub>International Anesthesia Research Society</pub><pmid>27782948</pmid><doi>10.1213/ANE.0000000000001530</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2999 |
| ispartof | Anesthesia and analgesia, 2017-01, Vol.124 (1), p.194-203 |
| issn | 0003-2999 1526-7598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1835646585 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Lung Injury - blood Acute Lung Injury - chemically induced Acute Lung Injury - physiopathology Acute Lung Injury - therapy Anesthetics, Inhalation - administration & dosage Anesthetics, Intravenous - administration & dosage Animals Anti-Inflammatory Agents - administration & dosage Biomarkers - blood Blood-Air Barrier - drug effects Blood-Air Barrier - metabolism Bronchoalveolar Lavage Fluid - chemistry Capillary Permeability - drug effects Cytokines - blood Cytokines - genetics Disease Models, Animal Hemodynamics - drug effects Inflammation Mediators - blood Kidney - drug effects Kidney - physiopathology Lipopolysaccharides Lung - drug effects Lung - metabolism Male Methyl Ethers - administration & dosage Oxygen - blood Pneumonia - blood Pneumonia - chemically induced Pneumonia - physiopathology Pneumonia - prevention & control Propofol - administration & dosage Rats, Wistar Respiration, Artificial Time Factors |
| title | Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T01%3A35%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sevoflurane%20Abolishes%20Oxygenation%20Impairment%20in%20a%20Long-Term%20Rat%20Model%20of%20Acute%20Lung%20Injury&rft.jtitle=Anesthesia%20and%20analgesia&rft.au=Kellner,%20Patrick&rft.date=2017-01-01&rft.volume=124&rft.issue=1&rft.spage=194&rft.epage=203&rft.pages=194-203&rft.issn=0003-2999&rft.eissn=1526-7598&rft_id=info:doi/10.1213/ANE.0000000000001530&rft_dat=%3Cproquest_cross%3E1835646585%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835646585&rft_id=info:pmid/27782948&rfr_iscdi=true |